Evidence map›Paper›PMID 40814379›Full record

ArticleAmerican journal of cancer research2025

La-related protein 1 drives malignant progression and epithelial-mesenchymal transition in anaplastic thyroid carcinoma.

Changtian Yin, Jinpeng Wen, Zhekuan Lv, Lingling Ding, Mojiao Lu, Yawen Guo, Lingli Jin, Xiabin Lan, Qingliang Wen, Chuanming Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Conserved Functions of LARP1 Proteins in Eukaryotes.Wiley interdisciplinary reviews. RNA
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Changtian YinOtolaryngology, Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College Hangzhou 310014, Zhejiang, China.
Jinpeng WenOtolaryngology, Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College Hangzhou 310014, Zhejiang, China.
Zhekuan LvPostgraduate Training Base Alliance of Wenzhou Medical University (Zhejiang Provincial People's Hospital) Wenzhou 325000, Zhejiang, China.
Lingling DingOtolaryngology, Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College Hangzhou 310014, Zhejiang, China.
Mojiao LuPostgraduate Training Base Alliance of Wenzhou Medical University (Zhejiang Provincial People's Hospital) Wenzhou 325000, Zhejiang, China.
Yawen GuoOtolaryngology, Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College Hangzhou 310014, Zhejiang, China.
Lingli JinOtolaryngology, Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College Hangzhou 310014, Zhejiang, China.
Xiabin LanZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences Hangzhou 310022, Zhejiang, China.
Qingliang WenZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences Hangzhou 310022, Zhejiang, China.
Chuanming ZhengOtolaryngology, Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College Hangzhou 310014, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anaplastic thyroid cancer (ATC) is an extremely aggressive and lethal malignancy characterized by a very short average survival time following diagnosis. Understanding the molecular mechanisms that drive this aggressiveness is vital for developing effective therapies. This study aimed to elucidate the role and function of La-related protein 1 (LARP1) in ATC progression. We quantitatively analyzed LARP1 expression in patient samples and ATC cell lines. Functional assays were performed to investigate LARP1's involvement in cancer-related processes, including inhibition of apoptosis, promotion of cell cycle progression, proliferation, colony formation, migration, and invasion. Our results revealed significantly elevated LARP1 expression in ATC tissues, which may be associated with poor patient prognosis. Experimental data demonstrated that LARP1 enhances oncogenic activities, promoting proliferative and invasive behaviors. These findings provide compelling evidence that LARP1 plays a crucial role in ATC malignancy, offering insights into pathophysiology and potential therapeutic targets.

Indexed as

Anaplastic thyroid cancerLARP1malignancytherapeutic target

Identifiers

PMID40814379
PMCPMC12344170

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.