ArticleAmerican journal of cancer research2025
Development and validation of nomogram models for predicting urinary incontinence following radical prostatectomy in high-risk prostate cancer patients.
Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo develop a risk stratification model for predicting urinary incontinence following radical prostatectomy (RP) in high-risk prostate cancer patients based on their clinicopathological characteristics.
methodsA retrospective analysis was conducted on 520 prostate cancer patients who underwent RP between January 2016 and January 2024. Baseline characteristics, pathological data, laboratory parameters, and surgery-related factors were collected. Urinary continence status at 1, 3, and 6 months postoperatively was assessed. Multivariate logistic regression analyses were performed to identify independent risk factors, and nomograms were constructed to predict urinary incontinence risk at each time point.
resultsUrinary incontinence rates at 1, 3, and 6 months postoperatively were 92.88%, 69.62%, and 23.65%, respectively. At 1 month, a higher Gleason score (OR=2.178, P=0.003) was a risk factor, while robot-assisted surgery was protective (OR=0.289, P=0.003). At 3 months, higher Gleason score (OR=1.565, P=0.004) increased risk, whereas lower BMI (<25 kg/m
conclusionsThe developed nomograms effectively stratify the risk of urinary incontinence following RP in high-risk patients, facilitating individualized perioperative management and rehabilitation strategies.
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