Evidence map›Paper›PMID 40814248›Full record

ArticleActa ophthalmologica2026

Risk of rhegmatogenous retinal detachment following pars plana vitrectomy for full-thickness macular hole and epiretinal membrane in pseudophakic eyes.

Birgitte Romme Nielsen, Morten la Cour, Mark Alberti, Ulrik Christensen, Thomas Scheike, Jakob Grauslund, Lonny Stokholm

Abstract read
In one paragraph

Article in Acta ophthalmologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Birgitte Romme NielsenDepartment of Ophthalmology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-9840-8036
Morten la CourDepartment of Ophthalmology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Mark AlbertiDepartment of Ophthalmology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Ulrik ChristensenDepartment of Ophthalmology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Thomas ScheikeDepartment of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
Jakob GrauslundDepartment of Regional Health Research, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0001-5019-0736
Lonny StokholmDepartment of Ophthalmology, Odense University Hospital, Odense, Denmark.

Funding

Candys FoundationFight for Sight - DenmarkHelsefondenMauritzen la Fontaine FoundationRH-OUH Research GrantSynoptik-Fonden
6 · The paper itself

Abstract

purposeTo estimate the risk of rhegmatogenous retinal detachment (RRD) following pars plana vitrectomy (PPV) for full-thickness macular hole (FTMH) or epiretinal membrane (ERM) in pseudophakic eyes.

methodsWe conducted a nationwide Danish registry-based cohort study from 2010 to 2023. Eyes entered the study at phacoemulsification surgery (age ≥ 50) and were followed until outcome (RRD), exposure (PPV), or censoring (death, end of study, or competing events). PPV was analysed as a time-dependent exposure occurring after phacoemulsification surgery, with eyes considered exposed from the time of PPV onwards.

resultsA total of 680 858 eyes were included. Median follow-up was 4.8 years (IQR, 2.5-7.9) after phacoemulsification and 5.0 years (2.5-7.9) after PPV, with a median interval of 76 days (39-328) between procedures. The 1-year cumulative incidence of RRD after PPV for FTMH was 0.62% (95% CI, 0.40-0.93), significantly higher in males. For ERM, it was 0.43% (0.27-0.66), with no sex difference. Compared to phacoemulsification alone, the hazard ratio (HR) for RRD was increased in males operated on for FTMH (HR 2.60; 1.62-4.17) and in females operated on for ERM (HR 1.93; 1.07-3.49). Among those who remained event-free 1 year postoperatively, no significant difference in RRD risk was observed between groups.

conclusionsPPV in pseudophakic eyes has a low risk of RRD but higher than that of phacoemulsification surgery after the first year, with notable sex variations for FTMH. Among those who remained event-free 1 year postoperative, no difference in RRD risk was observed between PPV and phacoemulsification surgery.

Indexed as

Epiretinal MembranePostoperative ComplicationsPseudophakiaRegistriesRetinal DetachmentRetinal PerforationsVitrectomyAgedAged, 80 and overDenmarkFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedERMFTMHincidencepars plana vitrectomyphacoemulsification surgeryrhegmatogenous retinal detachment

Identifiers

PMID40814248
PMCPMC12888938

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.