Evidence map›Paper›PMID 40814138›Full record

ArticleACS sensors2025

Low-Cost Polyphenol-Polypyrrole Molecularly Imprinted Sensor for Point-of-Care Alzheimer's Detection.

Ajith Mohan Arjun, Sudhaunsh Deshpande, Guoyi Liu, Daimei Miura, Krzysztof Pawlak, Tokuda Takahiko, Makoto Higuchi, Miyu Matsumoto, Tomoko Umemura, Kaori Tsukakoshi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS sensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ajith Mohan ArjunDavid Price Evans Global Health and Infectious Diseases Group, Pharmacology & Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 7BE, United Kingdom.
Sudhaunsh DeshpandeDavid Price Evans Global Health and Infectious Diseases Group, Pharmacology & Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 7BE, United Kingdom.ORCID 0009-0002-9711-1120
Guoyi LiuDavid Price Evans Global Health and Infectious Diseases Group, Pharmacology & Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 7BE, United Kingdom.
Daimei MiuraDepartment of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Koganei, Tokyo 184-8588, Japan.
Krzysztof PawlakMaterials Innovation Factory, University of Liverpool, 51 Oxford Street, Liverpool L7 3NY, United Kingdom.
Tokuda TakahikoAdvanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan.
Makoto HiguchiAdvanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan.
Miyu MatsumotoDepartment of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Koganei, Tokyo 184-8588, Japan.
Tomoko UmemuraDepartment of Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
Kaori TsukakoshiDepartment of Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.ORCID 0000-0003-4779-1113
Sanjiv SharmaDavid Price Evans Global Health and Infectious Diseases Group, Pharmacology & Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 7BE, United Kingdom.ORCID 0000-0003-3828-737X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is an urgent need for rapid, affordable diagnostics for Alzheimer's disease (AD), particularly those that can detect phosphorylated Tau 181 (p-tau181)─a key biomarker─directly in plasma. We present a scalable, label-free electrochemical biosensor fabricated on a printed circuit board platform, integrating a novel nanomolecularly imprinted polymer transducer based on a polyphenol red-polypyrrole composite. This platform enables sensitive detection of p-tau181 in undiluted plasma, serum, and clinical AD samples using a custom-designed potentiostat and machine learning-assisted classification. The sensor achieves a detection limit of 498 fg mL

Indexed as

Alzheimer DiseaseBiosensing TechniquesLimit of DetectionMolecular ImprintingPoint-of-Care SystemsPolyphenolsPyrrolesPolyphenolsPyrrolesAlzheimer’s diseaseelectrochemical biosensormolecularly imprinted polymer (MIP)phosphorylated tau 181 (p-tau181)point-of-care (POC) diagnosticspolyphenol red−polypyrrole (pPhR-pPy)

Identifiers

PMID40814138
PMCPMC12671001

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.