Evidence map›Paper›PMID 40814113›Full record

ArticleExperimental hematology & oncology2025

Elevated TIM3 expression on bone marrow T cells drives immune dysfunction in early relapsed blood cancer after allogeneic hematopoietic stem cell transplantation.

Thi Thuy Duong Pham, Su-Young Choi, Jeong Suk Koh, Bu-Yeon Heo, Sang-Woo Lee, Myung-Won Lee, Wonhyoung Seo, Yunseon Jang, Jung-Hyun Park, Deog-Yeon Jo and 3 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental hematology & oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Thi Thuy Duong Pham *Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, South Korea.
Su-Young Choi *Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, South Korea.
Jeong Suk Koh *Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, South Korea.
Bu-Yeon HeoDepartment of Medical Science, College of Medicine, Chungnam National University, Daejeon, South Korea.
Sang-Woo LeeDepartment of Medical Science, College of Medicine, Chungnam National University, Daejeon, South Korea.
Myung-Won LeeDepartment of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, South Korea.
Wonhyoung SeoDepartment of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, South Korea.
Yunseon JangTranslational Immunology Institute for Medical Science, College of Medicine, Chungnam National University, Daejeon, South Korea.
Jung-Hyun ParkTranslational Immunology Institute for Medical Science, College of Medicine, Chungnam National University, Daejeon, South Korea.
Deog-Yeon JoDepartment of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, South Korea.
Seungyeul YooDepartment of Genetics and Genomics Science, Icahn School of Medicine at Mount Sinai, NY, New York, USA. magicyoo@gmail.com.
Jaeyul KwonDepartment of Medical Science, College of Medicine, Chungnam National University, Daejeon, South Korea. kwonja@cnu.ac.kr.
Ik-Chan SongDepartment of Medical Science, College of Medicine, Chungnam National University, Daejeon, South Korea. petrosong@cnu.ac.kr.

Funding

grants from the Korean Society of Hematology Research Fund ICKSH-2023-04Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea RS-2020-KH088690National Research Foundation of Korea (NRF) grant funded by the Korea government NRF-2021R1C1C1012397research fund of Chungnam National University 2024
6 · The paper itself

Abstract

Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the leading cause of treatment failure in patients with hematologic malignancies. To better understand the mechanisms underlying early relapse (ER), we comprehensively explored the expression of inhibitory receptors (IRs) in bone marrow (BM) T cells at differentiation stage and examined transcriptional differences. Among the evaluated IRs, TIM3 was significantly upregulated in CD3

Indexed as

Allogeneic hematologic stem cell transplantation (HSCT)Double negative t cells (DNTs)Early relapse (ER)Inhibitor receptorsLeukemia immune microenvironmentRegulatory t cells (Treg)SabatolimabT cell immunoglobulin and mucin domain 3 (TIM3)

Identifiers

PMID40814113
PMCPMC12355862

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.