Observational studyBMC pregnancy and childbirth2025
Relationship between dietary protein intake and serum essential free amino acid concentrations in Japanese pregnant women: an observational study.
Observational study in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsufficient protein intake decreases serum free amino acid (FAA) concentrations and worse whole-body nutritional status, leading to poor pregnancy outcomes. Protein can be obtained from various dietary sources and differs in amino acid composition. However, it remains unclear whether FAA patterns and nutritional status are influenced by differences in dietary protein sources. Therefore, this study aimed to explore the relationship between serum FAAs, type of protein source intake, and protein nutritional status to improve diet during pregnancy.
methodsIn this secondary analysis of data from an observational study of pregnant Japanese women (n = 115), we examined the relationship between serum FAA concentrations, the intake of each protein source, and protein nutritional status. Serum FAA concentrations and protein nutritional biomarkers were measured, and the intake of each protein source was estimated using a brief self-administered diet history questionnaire.
resultsSerum FAA concentrations were significantly positively correlated with animal protein intake. Weight-adjusted total and animal protein intakes in the first tertile (T1) of the reduced albumin (Alb) ratio were significantly lower than those in the second and third tertiles (T2-3). Tryptophan concentrations in the second and third trimesters of pregnancy were significantly positively correlated with the reduced Alb ratio. Threonine in T1 of the reduced Alb ratio was significantly lower than that in T2-3 in the second trimester.
conclusionsIndividual FAA concentrations during pregnancy are affected differently according to the dietary protein source and intake. The intake of animal proteins is effective in maintaining essential FAAs during pregnancy. Protein deficiency may lead to decreased concentrations of serum tryptophan, threonine, and protein nutritional biomarkers. Identifying a proper strategy for ensuring adequate protein intake may contribute to healthy birth outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.