ArticleTropical diseases, travel medicine and vaccines2025
Safety of COVID-19 revaccination in patients with prior hypersensitivity reactions: a retrospective study.
Article in Tropical diseases, travel medicine and vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHypersensitivity reactions (HSR) to the COVID-19 vaccine have been reported. Despite these reactions, revaccination remains essential.
objectiveThis study aims to explore the potential outcomes of COVID-19 revaccination in individuals with prior vaccine-related adverse reactions.
methodsA retrospective study was employed with a sample of 225 patients, with HSR regarding COVID-19 vaccines, who were referred to a university hospital. Demographic data, vaccine types and HSR were collected.
resultsSeventy-seven percent (175/225) of patients were revaccinated post HSR. Out of the 175 patients, 57.1%, 34.2% and 8.5% had a history of HSR in connection to inactivated vaccines, viral vector vaccines, and mRNA vaccines, respectively. Sixty percent were revaccinated with the same type of vaccine and 63.4% received antihistamines and/or anti-leukotriene premedication. After revaccination, 89.1% did not have adverse reactions, while 10.9% had mild reactions. When comparing patients who experienced HSR following COVID-19 revaccination with those who did not exhibit reactions, a significant association among patients with revaccination adverse effects were a revaccination with inactivated vaccines; Sinovac-CoronaVac (P < 0.001), a history of any allergic diseases (P < 0.001) and underlying allergic rhinitis (P = 0.003). Premedication or change of vaccine type did not have an effect to the rate of adverse reactions reported post revaccinations.
conclusionsIn this study, COVID-19 revaccination in patients with a history of COVID-19 vaccine-related HSRs was generally safe, with most patients tolerating it well. However, individuals with underlying allergic conditions, particularly allergic rhinitis, exhibited a higher incidence of mild reactions, especially following revaccination with an inactivated vaccine.
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