Evidence map›Paper›PMID 40814026›Full record

ArticleACS applied bio materials2025

Cyanine-Based Dual-Emission Sensor for Ratiometric NAD(P)H Imaging in Cells, Renal Tissues, and Entire Organisms.

Peter Agyemang, Sushil K Dwivedi, Henry Lanquaye, Christina You, Alicia Guo, Ashlyn Colleen Beatty, Yan Zhang, Athar Ata, Thomas Werner, Haiying Liu

Abstract read
In one paragraph

Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Peter AgyemangDepartment of Chemistry, Michigan Technological University, Houghton, Michigan 49931, United States.
Sushil K DwivediDepartment of Chemistry, Michigan Technological University, Houghton, Michigan 49931, United States.ORCID 0000-0003-2744-9521
Henry LanquayeDepartment of Chemistry, Michigan Technological University, Houghton, Michigan 49931, United States.
Christina YouDepartment of Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States.
Alicia GuoDepartment of Chemistry, Michigan Technological University, Houghton, Michigan 49931, United States.
Ashlyn Colleen BeattyDepartment of Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States.
Yan ZhangDepartment of Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States.
Athar AtaDepartment of Chemistry, Michigan Technological University, Houghton, Michigan 49931, United States.
Thomas WernerDepartment of Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States.
Haiying LiuDepartment of Chemistry, Michigan Technological University, Houghton, Michigan 49931, United States.ORCID 0000-0001-8351-2017

Funding

Ratiometric Near-infrared Fluorescent Probes for Lysosomal pH in Living CellsR15GM114751 · NIGMS · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI LIU, HAIYING · 2015 to 2019
$798k
Near-infrared Fluorescent Probes for Sensitive Detection of NADH in Live CellsR15GM146206 · NIGMS · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI LIU, HAIYING · 2022 to 2024
$588k
High Urinary Phosphate Induces TLR4-mediated Inflammation and Cystogenesis in Polycystic Kidney DiseaseR15DK137195 · NIDDK · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI ZHANG, YAN · 2023 to 2023
$470k
NIDDK NIH HHS R15 DK137195NIGMS NIH HHS R15 GM114751NIGMS NIH HHS R15 GM146206
6 · The paper itself

Abstract

Monitoring the dynamic fluctuations of NADH and NADPH, key coenzymes in intracellular redox homeostasis and bioenergetics, is essential for understanding both normal physiology and disease pathology. However, precise, real-time imaging of NAD(P)H levels in complex biological systems remains a major challenge due to interference from endogenous fluorescence and the limitations of intensity-based sensors. We present a newly engineered dual-emission fluorescent sensor, sensor

Indexed as

Biocompatible MaterialsCarbocyaninesFluorescent DyesKidneyNADPAnimalsDrosophila melanogasterHumansMaterials TestingMolecular StructureOptical ImagingParticle SizeBiocompatible MaterialsCarbocyaninesFluorescent DyesNADPcyaninecyanine dyefluorescent sensorfruit fly larvaeNAD(P)Hratiometric imaging

Identifiers

PMID40814026
PMCPMC12442035

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.