Evidence map›Paper›PMID 40814020›Full record

ArticlemAbs2025

What does AlphaFold3 learn about antibody and nanobody docking, and what remains unsolved?

Fatima N Hitawala, Jeffrey J Gray

Abstract read
In one paragraph

Article in mAbs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Antibody-drug conjugate engineering: from design to efficacy and safety.Signal transduction and targeted therapy · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Adaptive Disorder as the Hallmark of Nanobodies Antigen-Binding Loops.Journal of chemical information and modeling · 2026
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Fatima N HitawalaDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-3042-1060
Jeffrey J GrayDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-6380-2324

Funding

Prediction of the Structures of Protein ComplexesR35GM141881 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI JEFFREY J GRAY · 2021 to 2026
$7.6M
NIGMS NIH HHS R35 GM141881
6 · The paper itself

Abstract

Antibody therapeutic development is a major focus in healthcare. To accelerate drug development, significant efforts have been directed toward the

Indexed as

AntibodiesMolecular Docking SimulationSingle-Domain AntibodiesSoftwareBinding Sites, AntibodyHumansAntibodiesSingle-Domain AntibodiesAlphaFold3Antibody dockingbenchmarknanobody dockingranking protocol

Identifiers

PMID40814020
PMCPMC12360200

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.