Evidence map›Paper›PMID 40814016›Full record

ArticleActa obstetricia et gynecologica Scandinavica2025

Perinatal outcomes and maternal health before and after single motherhood through assisted conception: A multiregistry study in Sweden.

Evangelia Elenis, Cecilia Mitt Holm, Ove Axelsson, Agneta Skoog Svanberg, Claudia Lampic, Gunilla Sydsjö

Abstract readMulticenter Study
In one paragraph

Article in Acta obstetricia et gynecologica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Evangelia ElenisDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-2253-4682
Cecilia Mitt HolmDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Ove AxelssonDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Agneta Skoog SvanbergDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Claudia LampicDepartment of Psychology, Umeå University, Umeå, Sweden.
Gunilla SydsjöDepartment of Obstetrics and Gynecology, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Funding

Akademiska Sjukhuset ALF 1040530/2019Akademiska Sjukhuset ALF-937815/2020Center for Clinical Research, Region Sörmland DLL-1014103Forskningsrådet i Sydöstra Sverige
6 · The paper itself

Abstract

introductionSingle motherhood by choice has been associated with increased perinatal risks and poorer psychological well-being for the families. However, limited evidence exists regarding the health status of these women before, during, and after pregnancy. MATERIAL AND

methodsThis prospective multiregistry study was conducted in Sweden and included unpartnered women conceiving with the help of assisted conception (n = 296) and all partnered women conceiving through IVF with the couple's own gametes (n = 7294), giving birth during 2007-2014. The primary outcomes assessed maternal somatic and mental health diagnoses 3 years before and after pregnancy, while secondary outcomes examined obstetric and neonatal complications. Data were retrieved from Swedish population-based registers, capturing ICD-10 diagnoses, filled prescriptions of psychiatric medications, and manually recorded perinatal data. Crude and adjusted logistic regression analyses were performed.

resultsSingle mothers through assisted conception were older and had significantly higher rates of smoking and obesity compared to partnered women. They also had a higher prevalence of psychiatric diagnoses, including anxiety and depression, both before (14.2% vs. 4.3%, p < 0.001) and after childbirth (29.1 vs. 12.1%, p < 0.001). Psychiatric medication use was significantly higher among single mothers both before (34.1% vs. 13.8%, p < 0.001) and after pregnancy (34.5% vs. 15.0%, p < 0.001). Obstetric and neonatal outcomes, including preterm birth and low birth weight, showed no significant differences between the groups, except for a higher incidence of multiple births among single mothers. The index population had a twofold increased risk of psychiatric conditions or medications, despite adjustment, in the period immediately before [aOR 2.51 (1.92-3.27)] or after childbirth [aOR 2.00 (1.51-2.66)].

conclusionsThe study reveals that single mothers through assisted conception face increased psychiatric risks before and after childbirth compared to partnered women undergoing autologous IVF. The findings highlight the need for careful eligibility assessment by healthcare professionals and underscore the importance of ensuring a robust support system to help these mothers manage the challenges of solo parenthood.

Indexed as

Maternal HealthPregnancy ComplicationsPregnancy OutcomeReproductive Techniques, AssistedSingle ParentAdultFemaleFertilization in VitroHumansInfant, NewbornMental DisordersPregnancyProspective StudiesRegistriesSwedenassisted reproductive technologiesdonor conceptionmental illnessperinatal outcomessingle motherhood by choice

Identifiers

PMID40814016
PMCPMC12575184

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.