Evidence map›Paper›PMID 40813990›Full record

ArticlePerioperative medicine (London, England)2025

Relationship between endotoxin core and staphylococcal antibody levels and outcome following transcatheter aortic valve implantation (TAVI).

Andrew Smith, James Fullerton, John Whittle, James Moon, Michael Mullen, Paul Scully, Colin Hamilton-Davies

Registry-linked trialAbstract read
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In one paragraph

Article in Perioperative medicine (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03029026 (A sTudy invesTigating the Role of Occult cArdiaC Amyloid in The Elderly With Aortic Stenosis), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03029026 completednot on this map

A sTudy invesTigating the Role of Occult cArdiaC Amyloid in The Elderly With Aortic Stenosis

TypeobservationalSponsorQueen Mary University of LondonRan2011 to 2021Enrolled581ConditionsCardiac Amyloidosis, Aortic StenosisArmsBaseline assessment, Transthoracic echocardiography, 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy, CT 3-5-minute post-contrast research sequences, Cardiac Magnetic Resonance
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrew SmithResearch Department of Interventional Medicine, Division of Surgery & Interventional Science, UCL, 2 Floor Charles Bell House, 43-45 Foley Street, London, W1W 7TS, UK. andrew.smith84@nhs.net.
James FullertonNDORMS, Medical Sciences Division, University of Oxford, Windmill Road, Headington, Oxford, OX3 7HE, UK.
John WhittleResearch Department of Interventional Medicine, Division of Surgery & Interventional Science, UCL, 2 Floor Charles Bell House, 43-45 Foley Street, London, W1W 7TS, UK.
James MoonInstitute of Cardiovascular Sciences, University College London, Gower Street, London, WC1E 6BT, UK.
Michael MullenBartholomew's Hospital, West Smithfield, London, EC1A 7BE, UK.
Paul ScullyInstitute of Cardiovascular Sciences, University College London, Gower Street, London, WC1E 6BT, UK.
Colin Hamilton-DaviesResearch Department of Interventional Medicine, Division of Surgery & Interventional Science, UCL, 2 Floor Charles Bell House, 43-45 Foley Street, London, W1W 7TS, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMorbidity and mortality following aortic valve surgery is high. Low antibody levels to endotoxin core and to staphylococcus is associated with poor outcome following cardiac surgery. Transcatheter aortic valve implantation (TAVI) is an alternative treatment to surgery. This study examines the relationship between antibody levels and outcome following TAVI.

methodsUsing enzyme-linked immunosorbent assays (ELISA), we measured pre-procedure levels of antibodies to endotoxin core (EndoCAb) and 2 common staphylococcal epitopes on saved serum of 112 adult patients scheduled to undergo elective TAVI. Primary outcome measure was post-procedure length of stay (LOS) in hospital with secondary outcome being development of infective complications. Correlations were examined using Spearman rank order or Kendall Tau-b methods. Patients were quartiled according to antibody levels and outcomes compared between quartile groups. Differences between groups were examined using Student t-test, one-way ANOVA, and Kruskal-Wallis tests.

resultsOne hundred twenty-two patients (64 M, 58 F) were recruited with mean age of 86 years. Little correlation was seen between any of the individual antibody levels or combined ranked antibody level with length of stay following TAVI (correlation coefficients-teichoic acid r

conclusionsThis study indicates that there is little association between post-procedural length of stay in hospital following TAVI and pre-procedural antibody levels to endotoxin or staphylococcus, unlike that seen with surgical patients. Understanding this relationship may enable improved selection of therapeutic options for patients with impaired immunity needing aortic valve interventions.

trial registrationThe patients in this study are a sub-group of a larger observational cohort study looking at the prevalence of cardiac amyloid in the elderly with aortic stenosis in those patients undergoing transcatheter aortic valve replacement. CLINICALTRIALS: gov Identifier: NCT03029026.

Indexed as

Cardiac surgical proceduresCore endotoxinImmunityStaphylococcusTAVITranscatheter aortic valve implantation

Identifiers

PMID40813990
PMCPMC12351906

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