Evidence map›Paper›PMID 40813976›Full record

ArticleBMC psychiatry2025

Cortical activation and functional connectivity in patients with chronic insomnia based on working memory tasks: a multi-channel near-infrared spectroscopy study.

Qi Zhou, Chang Yu, Zhiwang Liu, Qiao Wang, Jieqiong Bao, Chang Li, Haihang Yu, Dongsheng Zhou

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In one paragraph

Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Qi Zhou *Department of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, Zhejiang, China.
Chang Yu *Department of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, Zhejiang, China.
Zhiwang LiuDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, Zhejiang, China.
Qiao WangDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, Zhejiang, China.
Jieqiong BaoDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, Zhejiang, China.
Chang LiDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, Zhejiang, China.
Haihang YuDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, Zhejiang, China. yuhaihang0414@sina.com.
Dongsheng ZhouDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, Zhejiang, China. wyzhouds@sina.com.

Funding

Ningbo Natural Science Foundation Project No. 2021J275, No. 2022J269Ningbo Public Welfare Project No. 2022S022Ningbo Top Medical and Health Research Program No.2022030410the Natural Science Foundation of Zhejiang No.LTGD24H090001the Ningbo Clinical Medical Research Centre for Mental Health No.2022L002the Ningbo medical and health brand discipline No.PPXK 2024-07
6 · The paper itself

Abstract

backgroundWorking memory (WM) impairment has been found in patients with insomnia, and the frontotemporal region plays a central role in working memory. Therefore, changes in functional connectivity in the frontotemporal region may play an important role in WM impairment in patients of chronic insomnia, but little is known about the neural processes associated with WM dysfunction in patients with chronic insomnia. This study used functional near-infrared spectroscopy (fNIRS) to investigate differences in cortical activation and functional connectivity during a WM task between patients with chronic insomnia and healthy controls (HCs).

methodA total of 88 patients with chronic insomnia, as well as 84 HCs, were recruited. We used a WM task in which participants were asked to memorize and make choices based on the presented stimulation (graphics and colors). The WM task was divided into a block range set at baseline, a WM stimulation range set, a WM exploration range set, and a no WM (NWM) exploration range set. The oxygenated haemoglobin (Oxy-Hb) concentration in the frontotemporal lobe of the participants during the performance of the WM task was monitored using fNIRS, and brain functional connectivity and cortical activation in different brain regions were examined in patients with chronic insomnia.

resultsBehavioral tasks showed that the accuracy of patients with chronic insomnia was significantly lower than that in the HCs. The fNIRS showed that during the WM stimulation phase of the WM task, the oxy-Hb values of bilateral medial prefrontal cortex (mPFC) and dorsolateral PFC (DLPFC) in patients with chronic insomnia were significantly lower than those in HCs, while no significant differences were found in other brain regions. The average connection strength between different channels in patients with chronic insomnia is lower than that in the HCs. Further functional connectivity calculations for different brain regions revealed that the HCs had significantly higher connection strengths between four pairs of brain regions than the patients with chronic insomnia.

conclusionsThis study found that patients with chronic insomnia exhibited decreased activation and abnormal functional connectivity in bilateral mPFC regions during the WM task, suggesting that chronic insomnia showed damage to relevant brain regions during WM processing, which provides an objective theoretical basis for explaining WM impairment in patients with chronic insomnia.

Indexed as

Cerebral CortexMemory, Short-TermSleep Initiation and Maintenance DisordersAdultCase-Control StudiesFemaleHumansMaleMiddle AgedPrefrontal CortexSpectroscopy, Near-InfraredCerebral cortexChronic insomniaFunctional near-infrared spectroscopyOxy-haemoglobinWorking memory

Identifiers

PMID40813976
PMCPMC12351788

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.