ArticleMetabolomics : Official journal of the Metabolomic Society2025
Identification of altered metabolites in Rheumatic Heart Disease patients with atrial fibrillation and normal sinus rhythm using untargeted LC-MS metabolomics.
Article in Metabolomics : Official journal of the Metabolomic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Metabolomic signatures of early pathway disruptions and clinical outcomes in community-acquired pneumonia: a prospective case-control study.BMC pulmonary medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
INTRODUCTION &
objectiveRheumatic Heart Disease (RHD) is the commonest cause of atrial fibrillation (AF) in India with higher prevalence in younger population. The clinical significance of the differential metabolites in RHD patients with AF is unknown. This is a tertiary hospital-based study aimed to discover the metabolites associated with AF and normal sinus rhythm (NSR) in RHD patients using untargeted LCMS approach.
methodsIn this case control study, a total of 87 patients (38 persistent AF and 49 NSR) were incorporated after screening, including 12-lead ECG (electrocardiogram), 2D Echo (two-dimensional echocardiography) and a 24-hr Holter examination for NSR patients to exclude silent AF. Blood samples were collected and differentially expressed metabolites were identified using untargeted LCMS approach.
resultsAll the patients of our study belong to NYHA (New York Heart Association) classes II and III. The number of female patients was more in both groups. The mean age of the patients was 35.81 ± 7.96 and 29.61 ± 8.18 year in AF and NSR group respectively. 33 metabolites showed significantly altered expression - 15 upregulated and 18 down regulated metabolites. Pathway analysis showed that the altered metabolites were involved in Arginine, Phenylalanine tyrosine and tryptophan biosynthesis, D-Glutamine and D-glutamate, Alanine aspartate and glutamate metabolism, Arginine and proline metabolism.
conclusionsThe findings suggest that differential metabolites in RHD patients may help in identifying the high-risk group and possible therapeutic targets.
Indexed as
Identifiers
40813947What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.