ArticleNature microbiology2025
Aspergillus fumigatus dsRNA virus promotes fungal fitness and pathogenicity in the mammalian host.
Article in Nature microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- An ancestral mitochondrial DNA insertion disrupts RNAi and enables persistence of a novel mycovirus inbioRxiv : the preprint server for biology · 2026Article
- Genomic Characterization of a Novel Victorivirus Detected in a Sample Derived From a Human-Biting Tick in Japan.Microbiology and immunology · 2026Article
- The yeast mitochondrial porin represses Snf1/AMP kinase signaling to attenuate viral replication.Genetics · 2026Article
- Trans-Kingdom dsRNA Sensing:bioRxiv : the preprint server for biology · 2026Article
- Article
- Mycoviruses diversity in the black kōji mold, Aspergillus luchuensis (section Nigri) isolated from liquor-production environments in Japan.Virus research · 2026Article
- Mycoviruses in Entomopathogenic Fungi.Viruses · 2025Review
- Cytosolic receptors and signaling in antifungal immunity.The EMBO journal · 2025Review
- Aspergillus fumigatus dsRNA virus promotes fungal fitness and pathogenicity in the mammalian host.Nature microbiology · 2025Article
- Mycoviruses at the Crossroads: Molecular Mechanisms, Cross-Kingdom Interactions, and Abiotic Stress in the Phytobiome.Physiologia plantarumReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Aspergillus fumigatus accounts for approximately 65% of all invasive fungal infections in humans, with mortality rates from aspergillosis approaching 50%. Fungal virulence in plant pathogenic fungi can be modulated by viruses that infect fungi, also known as mycoviruses. However, their impact on fungal pathogenesis in mammals has remained largely unexplored. Here, utilizing an A. fumigatus strain naturally infected with the double-stranded RNA virus, A. fumigatus polymycovirus-1M (AfuPmV-1M), we found that the mycovirus confers a substantial survival advantage to the fungus under oxidative stress, heat stress and within the murine lung. Virus-cured fungal strains exhibited reduced conidiation, melanin production and levels of proteins involved in RNA metabolism and stress response, resulting in diminished fitness and virulence in mice. Finally, antiviral treatment during infection reduced AfuPmV-1M viral load, leading to improved survival in infected mice. Taken together, these data suggest that mycoviruses play an important and often underappreciated role as molecular 'backseat drivers' in fungal fitness, stress tolerance and disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.