ArticleSurgical endoscopy2025
Indocyanine green fluorescence-guided imaging enhances the efficiency and accuracy of inferior mesenteric artery lymph node dissection in rectal cancer.
Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Progress in the Design and Clinical Application of Probes for Fluorescence-Guided Laparoscopic Surgery.Chemical & biomedical imaging · 2026Review
- Fluorescence-guided surgery in colorectal cancer: current evidence, quantitative advances, and future perspectives.Annals of coloproctology · 2026Review
- Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundIndocyanine green fluorescence-guided imaging (ICG-FGI) enhances surgical precision in rectal cancer procedures; however, it is technically demanding. This study evaluated the effects of ICG-FGI on the efficacy of lymphadenectomy during radical rectal cancer surgery.
methodsThis multi-center retrospective cohort study analyzed patients who underwent laparoscopic radical resection for rectal cancer between January 2021 and December 2024. The participants were stratified into two cohorts (ICG and non-ICG groups) using 1:1 propensity score matching to ensure balanced baseline characteristics. The ICG group received a submucosal ICG injection 24 h preoperatively with intraoperative fluorescence laparoscopy navigation, whereas the non-ICG group underwent standard laparoscopy. Linear and logistic regression assessed determinants of lymph node yield and inferior mesenteric artery (IMA) lymph node metastasis, respectively. Diagnostic value of ICG-FGI in detecting IMA lymph node metastasis was assessed.
resultPatients with rectal cancer were enrolled from two centers with comparable baseline characteristics. Propensity score matching (1:1) yielded 141 matched pairs (ICG vs. non-ICG) for comparative analysis. The ICG cohort exhibited superior lymph node resection (21 vs. 17, P < 0.001) and higher number of patients with metastatic IMA lymph nodes detected (15.6 vs. 5.7%, P = 0.007). Multivariate linear regression analysis demonstrated that ICG-FGI was an independent predictor of enhanced nodal yield. Logistic regression analysis revealed that ICG-FGI technology significantly improved the detection rate of metastatic IMA lymph nodes. ICG-FGI sensitivity for detecting metastatic IMA station was 73.3%. Negative predictive value was 94.33% for non-fluorescent stations. Subgroup analysis revealed 75.00, 54.55, and 86.67% sensitivities for pT2, pT3, and pT4 tumors, respectively.
conclusionICG-FGI improves the precision of lymph node dissection during rectal cancer surgery, enhances pathological staging accuracy via superior detection of metastatic IMA nodes, and guides personalized treatment strategies for advanced-stage disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.