Evidence map›Paper›PMID 40813881›Full record

ArticleScientific reports2025

Extensive digital health technology assessment detects subtle motor impairment in mild and asymptomatic Pompe disease.

Andrea Pilotto, Beatrice Labella, Andrea Rizzardi, Cinzia Zatti, Chiara Trasciatti, Clint Hansen, Robbin Romijnders, Johanna Geritz, Filomena Caria, Barbara Risi and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Andrea PilottoDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. andrea.pilotto@unibs.it.
Beatrice LabellaDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Andrea RizzardiDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Cinzia ZattiDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Chiara TrasciattiDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Clint HansenDepartment of Neurology, Kiel University, Kiel, Germany.
Robbin RomijndersDepartment of Neurology, Kiel University, Kiel, Germany.
Johanna GeritzDepartment of Neurology, Kiel University, Kiel, Germany.
Filomena CariaNeMO-Brescia Clinical Center for Neuromuscular Diseases, Brescia, Italy.
Barbara RisiNeMO-Brescia Clinical Center for Neuromuscular Diseases, Brescia, Italy.
Simona DamioliNeMO-Brescia Clinical Center for Neuromuscular Diseases, Brescia, Italy.
Stefano Cotti PiccinelliDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Emanuele OlivieriDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Lucia FerulloDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Loris PoliDepartment of Continuity of Care and Frailty, Unit of Neurology, ASST Spedali Civili, Brescia, Italy.
Walter MaetzlerDepartment of Neurology, Kiel University, Kiel, Germany.
Alessandro PadovaniDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Massimiliano FilostoDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this case-control study was to evaluate the ability of digital health technology (DHT) to detect and quantify mobility alterations in late-onset Pompe Disease. The study enrolled eight subjects with Pompe Disease, including three young mildly affected/asymptomatic subjects, who underwent an extensive DHT mobility assessment and were contrasted to 52 matched controls. DHT enabled the detection of subtle mobility alterations, indicating a lower speed in walking, and worse performances in postural transition and turning in patients compared to controls. Interestingly, in the three mildly affected/asymptomatic cases, step time variability and step length showed detectable alterations compared to controls, despite scores within the normal range on clinical scales and timed tests.

Indexed as

Digital TechnologyGlycogen Storage Disease Type IIAdultCase-Control StudiesFemaleHumansMaleMiddle AgedWalkingDigital health technologyDigital technologyMobilityPompe diseaseProgression

Identifiers

PMID40813881
PMCPMC12354901

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.