Evidence map›Paper›PMID 40813704›Full record

ArticleJournal of cardiothoracic surgery2025

Predicting spread through air space of lung adenocarcinoma based on deep learning and machine learning models.

Zengming Wang, Lingxin Kong, Bin Li, Qingtao Zhao, Xiaopeng Zhang, Huanfen Zhao, Wenfei Xue, Wei Li, Shun Xu, Guochen Duan

Abstract read
In one paragraph

Article in Journal of cardiothoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zengming WangDepartment of Thoracic Surgery, Hebei General Hospital, NO. 348 Heping West Road, Xinhua District, Shijiazhuang, Hebei, 050000, P.R. China.
Lingxin KongDepartment of Thoracic Surgery, Hebei General Hospital, NO. 348 Heping West Road, Xinhua District, Shijiazhuang, Hebei, 050000, P.R. China.
Bin LiDepartment of Thoracic Surgery, Hebei General Hospital, NO. 348 Heping West Road, Xinhua District, Shijiazhuang, Hebei, 050000, P.R. China.
Qingtao ZhaoDepartment of Thoracic Surgery, Hebei General Hospital, NO. 348 Heping West Road, Xinhua District, Shijiazhuang, Hebei, 050000, P.R. China.
Xiaopeng ZhangDepartment of Thoracic Surgery, Hebei General Hospital, NO. 348 Heping West Road, Xinhua District, Shijiazhuang, Hebei, 050000, P.R. China.
Huanfen ZhaoDepartment of Pathology, Hebei General Hospital, Shijiazhuang, Hebei, 050000, China.
Wenfei XueDepartment of Thoracic Surgery, Hebei General Hospital, NO. 348 Heping West Road, Xinhua District, Shijiazhuang, Hebei, 050000, P.R. China.
Wei LiDepartment of Geriatric Cardiovascular, Hebei General Hospital, Shijiazhuang, Hebei, 050000, China.
Shun XuDepartment of Thoracic Surgery, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, 110000, China. xushuncmu1h@sina.com.
Guochen DuanDepartment of Thoracic Surgery, Hebei General Hospital, NO. 348 Heping West Road, Xinhua District, Shijiazhuang, Hebei, 050000, P.R. China. duanguoc@126.com.

Funding

Hebei Provincial Key Research Projects 22377790D
6 · The paper itself

Abstract

objectiveThe aim of this study was to develop a machine learning model that can predict spread through air space (STAS) of lung adenocarcinoma preoperatively. STAS is associated with poor prognosis in invasive lung adenocarcinoma. Therefore non-invasive and accurate pre-surgical prediction of STAS in patients with lung adenocarcinoma is essential for individualised patient management.

methodsWe included 138 patients with invasive lung adenocarcinoma who underwent lobectomy, collected their preoperative imaging data and clinical features, built a model for predicting STAS using machine learning and deep learning methods, and validated the efficacy of the model. Finally a nomogram was created based on logistic regression (LR).

resultsImaging histology features showed good model efficacy in both the training set (LR AUC = 0.764) and the test set (LR AUC = 0.776), and we combined the imaging histology and clinical features to jointly build a nomogram graph (AUC = 0.878), extracted the deep learning features, and built a machine learning model based on the ResNET50 algorithm, where the LR AUC = 0.918.

conclusionsThis presented radiomics model can be served as a non-invasive for predicting STAS in Infiltrating lung adenocarcinoma.

Indexed as

Adenocarcinoma of LungDeep LearningLung NeoplasmsMachine LearningAgedFemaleHumansMaleMiddle AgedNomogramsPneumonectomyPrognosisRetrospective StudiesTomography, X-Ray Computed

Identifiers

PMID40813704
PMCPMC12351919

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.