ArticleRadiation oncology (London, England)2025
CBCT-based online adaptive radiotherapy of the bladder - geometrical and dosimetrical considerations compared to conventional IGRT.
Article in Radiation oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Development of CBCT-Guided Online Adaptive Radiotherapy.Cancers · 2026Review
- CBCT based online daily adaptive treatment improves target coverage with limited benefit for OAR protection in SBRT prostate cancer.Radiation oncology (London, England) · 2026Article
- Online adaptive radiation therapy for muscle-invasive bladder cancer: short-course and high-precision definitive treatment for elderly or medically fragile patients.Japanese journal of radiology · 2026Article
- Solution for the hot spots in adaptive radiotherapy planning for cervical cancer: a case report and review of literature.Frontiers in oncology · 2026Article
- Daily artificial intelligence-assisted adaptive small margin radiotherapy during trimodal therapy of muscle-invasive bladder cancer.Frontiers in oncology · 2026Article
- Dosimetric impact of bladder volume variation on online adaptive radiotherapy for cervical cancer based on cone-beam computed tomography and clinical management strategies.Quantitative imaging in medicine and surgery · 2025Article
- CBCT-based Online Adaptive Radiotherapy for Prostate Cancer: Dosimetrical Aspects and Comparison to Non-Adaptive Conventional IGRT.Technology in cancer research & treatmentArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBladder cancer radiotherapy presents unique challenges due to the dynamic anatomy of the bladder and the surrounding organs. Conventional image-guided radiotherapy (IGRT) relies on fixed treatment margins and daily couch corrections, which can result in suboptimal dose delivery. Cone Beam Computed Tomography (CBCT)-based online adaptive radiotherapy (oART) allows daily re-optimization of treatment plans, potentially improving target dose coverage while minimizing exposure to organs at risk (OAR). This study compares oART with IGRT in bladder cancer patients.
methods160 oART fractions delivered using the Ethos system (Varian Medical Systems, Palo Alto, CA, USA) were analyzed and compared to conventional IGRT. For each adaptive fraction (fx), three plans were evaluated: the scheduled plan (initial plan recalculated based on daily CBCT), the adapted plan (re-optimized to daily anatomy), and the verification plan (dose distribution recalculated on the verification CBCT - vCBCT). Geometric variations, dose-volume parameters and treatment times were analyzed. Clinical plan acceptability was assessed using predefined dose-volume parameters. Dose coverage on the target's surface was analyzed using a novel method and visualized via Mercator projections.
resultsDespite drinking guidelines, bladder volumes varied significantly day-to-day. Dose coverage of the clinical target volume (CTV) improved significantly with adaptation (median D
conclusionsTreatment times were approximately 1.5 times longer than IGRT; however, CBCT-based oART enhanced target dose coverage, reduced OAR doses, and decreased variability in both target and OAR doses compared to IGRT, while also improving plan acceptability, although the results should be interpreted with caution due to the limited sample size and single-center design.
trial registrationNot applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.