Evidence map›Paper›PMID 40813589›Full record

ArticleNPJ science of food2025

Polysaccharides derived from Rosa rugosa cv. Plena ameliorate colorectal cancer by regulating intestinal microbiota composition and lipid metabolism pathway.

Chunyu Dai, Xuan Zheng, Jingxin Zhu, Hongxing Zhang, Junhua Jin, Xiaona Pang, Xiangyang Li, Yuanhong Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chunyu DaiBeijing Laboratory of Food Quality and Safety, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, China.
Xuan ZhengBeijing Laboratory of Food Quality and Safety, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, China.
Jingxin ZhuBeijing Laboratory of Food Quality and Safety, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, China.
Hongxing ZhangBeijing Laboratory of Food Quality and Safety, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, China.
Junhua JinBeijing Laboratory of Food Quality and Safety, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, China.
Xiaona PangBeijing Laboratory of Food Quality and Safety, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, China.
Xiangyang LiBeijing Laboratory of Food Quality and Safety, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, China. lxy2002cn@163.com.
Yuanhong XieBeijing Laboratory of Food Quality and Safety, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, China. xieyuanh@163.com.

Funding

Classification Development of Beijing Municipal Universities-Construction of Urban Agriculture and Forestry Characteristic Teacher Team 11000024T000002961733
6 · The paper itself

Abstract

This study elucidates the anti-colorectal cancer (CRC) mechanism of Rosa rugosa cv. Plena polysaccharide RPP1 against AOM/DSS-induced carcinogenesis. Purified via water extraction and chromatography, RPP1 was characterized as an eight-monosaccharide polymer by HPLC. In CRC mice, RPP1 administration reduced colonic polyp formation and ameliorated colon shortening while normalizing elevated serum IL-1β and TNF-α levels. Integrated multi-omics analyses revealed RPP1 remodeled gut microbiota composition through suppression of pro-inflammatory Bacteroides and Desulfovibrio concurrent with enrichment of beneficial Eubacterium and Muribaculum. These microbial shifts were associated with downregulation of fecal phosphatidylcholine (PC) and lysophosphatidylcholine (LPC), perturbing ether lipid, glycerophospholipid and sphingolipid metabolism. Mechanism correlation analysis further indicated Muribaculum/Clostridium modulation mediated RPP1's regulation of LPC levels. Transcriptomics confirmed suppression of lipid-metabolism pathways alongside activation of NOD-like receptor (NLR) and PPAR immune signaling. Collectively, RPP1 alleviates CRC through multifaceted modulation of gut microbiota, lipidomic remodeling, and immune pathway activation.

Identifiers

PMID40813589
PMCPMC12354799

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.