Evidence map›Paper›PMID 40813537›Full record

ArticleApoptosis : an international journal on programmed cell death2025

GSDME-dependent astrocyte pyroptosis promotes the progression of neuroinflammation in experimental cerebral malaria.

Jun Wang, Qinghao Zhu, Guodong Tong, Kangjie Yu, Jiao Liang, Yuxiao Huang, Yi Wang, Chao Yang, Tong Li, Weilu Liang and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jun Wang *Department of Medical Microbiology and Parasitology, Air Force Medical University, Xi'an, China.
Qinghao Zhu *Department of Medical Microbiology and Parasitology, Air Force Medical University, Xi'an, China.
Guodong Tong *College of Life Sciences, Northwest University, Xi'an, China.
Kangjie YuDepartment of Pathology, Air Force Hospital of Eastern Theater, Nanjing, China.
Jiao LiangDepartment of Medical Microbiology and Parasitology, Air Force Medical University, Xi'an, China.
Yuxiao HuangDepartment of Medical Microbiology and Parasitology, Air Force Medical University, Xi'an, China.
Yi WangDepartment of Medical Microbiology and Parasitology, Air Force Medical University, Xi'an, China.
Chao YangCollege of Life Sciences, Northwest University, Xi'an, China.
Tong LiCollege of Basic Medical Sciences, Yan'an University, Yan'an, China.
Weilu LiangSchool of Basic Medical Sciences, Air Force Medical University, Xi'an, China.
Ganze LiDepartment of Medical Microbiology and Parasitology, Air Force Medical University, Xi'an, China.
Xiaoran LiuSchool of Basic Medical Sciences, Air Force Medical University, Xi'an, China.
Jiayi SunCollege of Life Sciences, Northwest University, Xi'an, China.
Yinghui LiDepartment of Medical Microbiology and Parasitology, Air Force Medical University, Xi'an, China. 375576040@qq.com.
Yan ShenDepartment of Medical Microbiology and Parasitology, Air Force Medical University, Xi'an, China. 37762810@qq.com.
Ya ZhaoDepartment of Medical Microbiology and Parasitology, Air Force Medical University, Xi'an, China. zhaoya@fmmu.edu.cn.

Funding

National Natural Science Foundation of China 82072298National Natural Science Foundation of China 82302555National Natural Science Foundation of China NO. 82002158Natural Science Foundation of Shaanxi Province 2023-YBSF-449Natural Science Foundation of Shaanxi Province 2025SF-YBXM-417
6 · The paper itself

Abstract

Cerebral malaria (CM), a life-threatening neurological complication of Plasmodium falciparum infection, is characterized by severe neuroinflammation and long-term neurological sequelae. Central nervous system inflammation, driven by brain-infiltrated CD8

Indexed as

AstrocytesMalaria, CerebralNeuroinflammatory DiseasesPyroptosisAnimalsBlood-Brain BarrierBrainCD8-Positive T-LymphocytesDisease Models, AnimalDisease ProgressionInterferon-gammaMiceMice, Inbred C57BLInterferon-gammaAstrocyteCerebral malariaGSDMENeuroinflammationPyroptosis

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.