SynthesisInternational journal of colorectal disease2025
Cytoreductive surgery for colorectal peritoneal metastasis in the era modern systemic therapies: a systematic review and meta-analysis of survival outcomes.
Synthesis in International journal of colorectal disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
introductionThe value of surgical cytoreduction over modern systemic therapy in patients with colorectal peritoneal metastasis is debated. The present systematic review and meta-analysis aimed to determine the magnitude of the benefit of cytoreduction for peritoneal metastasis over varying intensities of palliative therapies.
methodsThe databases searched were PubMed, Cochrane Library, Scopus, CINHAL (EBSCO) and Google Scholar. The risk of bias was assessed using the RoB2 tool for randomized studies and the Newcastle-Ottawa scale for non-randomised studies. The certainty of the evidence was assessed using the GRADE Pro tool. The analysis used the log hazard ratio as the outcome measure for survival data with the random-effects model. Sensitivity analyses and meta-regressions were performed to establish the robustness of the results.
resultsThe quantitative meta-analysis included two randomised and nine non-randomized studies with 3316 patients. The pooled hazard ratio for overall survival was 0.447 (95% CI: 0.387 to 0.595; p-< 0.001) favouring cytoreduction without statistical heterogeneity (I
conclusionsCurative intent treatment of colorectal peritoneal metastasis by adding cytoreductive surgery over systemic chemotherapy alone, increased the OS by a large magnitude with moderate certainty of evidence, irrespective of the systemic therapy used.
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