ArticleBrain imaging and behavior2025
Cerebral network topology and peak width of skeletonized mean diffusivity changes associated with cognitive impairment in patients with obstructive sleep apnea.
Article in Brain imaging and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advancements in pediatric obstructive sleep apnea: cognitive implications and the role of AI in precision medicine.Frontiers in medicine · 2025Pooled it
- Altered brain glucose metabolism and connectivity in young adults with obstructive sleep apnea.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
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7 authors.
Funding
Abstract
objectivesTo characterize the network topology and peak width of skeletonized mean diffusivity (PSMD) and their correlation with cognitive impairment in obstructive sleep apnea (OSA) patients and to assess whether such impairments are reversible after treatment.
methodsNinety-one OSA patients and 30 healthy controls (HCs) participated. Patients were classified into mild group (n = 37) and moderate-severe group (n = 54) based on apnea-hypopnea index. Cognitive performances, including execution, visual memory, attention, and psychomotor speed were assessed. Network topological properties and PSMD, derived from resting-state functional MRI and diffusion imaging, were compared and correlated with their cognitive performance. Alterations in network topology, PSMD, and cognitive performance after treatment were assessed in a subcohort of patients.
resultsOSA patients had worse performance in the digit symbol test and Stroop color-word test than HCs, whereas the performance of moderate-severe OSA patients decreased more significantly. Mild OSA patients had compromised degree centrality of cognitive control, while moderate-severe OSA patients had compromised topological properties involving cognitive control, default mode, limbic, and auditory network relative to HCs, and had higher PSMD than mild OSA patients and HCs. Aberrant PSMD and functional nodal network metrics closely correlated with cognitive decline in OSA patients. Notably, functional network topology and cognitive performance partially improved in patients after treatment.
conclusionsProgressive compromise of the PSMD and functional network topology may underlie the cognitive deficits in attention and processing speed in OSA patients. The disruption of functional network topology and cognitive performance are partially reversible in OSA patients after treatment.
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