Evidence map›Paper›PMID 40813379›Full record

ArticleNPJ Parkinson's disease2025

Increased frontal [

Elina Jaakkola, Jani Ijas, Juho Joutsa, Tero Vahlberg, Elina Myller, Mikael Eklund, Simo Nuuttila, Kirsi Murtomäki, Tuomas Mertsalmi, Reeta Levo and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elina Jaakkola *Clinical Neurosciences, University of Turku, Turku, Finland. elanja@utu.fi.
Jani Ijas *Clinical Neurosciences, University of Turku, Turku, Finland.
Juho JoutsaClinical Neurosciences, University of Turku, Turku, Finland.
Tero VahlbergDepartment of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland.
Elina MyllerClinical Neurosciences, University of Turku, Turku, Finland.
Mikael EklundClinical Neurosciences, University of Turku, Turku, Finland.
Simo NuuttilaClinical Neurosciences, University of Turku, Turku, Finland.
Kirsi MurtomäkiDepartment of Neurology, Helsinki University Hospital and Department of Clinical Neurosciences (Neurology), University of Helsinki, Helsinki, Finland.
Tuomas MertsalmiDepartment of Neurology, Helsinki University Hospital and Department of Clinical Neurosciences (Neurology), University of Helsinki, Helsinki, Finland.
Reeta LevoDepartment of Neurology, Helsinki University Hospital and Department of Clinical Neurosciences (Neurology), University of Helsinki, Helsinki, Finland.
Tommi NoponenDepartment of Clinical Physiology, Nuclear Medicine, Turku PET Centre and Medical Physics, Turku University Hospital and Wellbeing services county of Southwest Finland, Turku, Finland.
Toni IhalainenDepartment of Clinical Physiology and Nuclear Medicine, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Filip ScheperjansDepartment of Neurology, Helsinki University Hospital and Department of Clinical Neurosciences (Neurology), University of Helsinki, Helsinki, Finland.
Valtteri KaasinenClinical Neurosciences, University of Turku, Turku, Finland. valtteri.kaasinen@tyks.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid eye movement (REM) sleep behavior disorder (RBD) is a frequent non-motor symptom of Parkinson's disease (PD) and a potential early marker of synucleinopathy-related neurodegeneration. While striatal dopaminergic dysfunction in PD-RBD has been extensively studied, the role of extrastriatal monoaminergic alterations -particularly those involving serotonin - remains poorly understood. In this study, 155 PD patients underwent [

Identifiers

PMID40813379
PMCPMC12354797

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.