Evidence map›Paper›PMID 40813233›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Combination Image-Guided and Antibody-Targeted α-Therapy Before Targeted Immunotherapy for Treatment of Solid Tumors.

Maciej Kujawski, Eric Aniogo, Patty Wong, Susanta Hui, Hemendra Ghimire, Erasmus K Poku, Paul J Yazaki, Jeffrey Y C Wong, John E Shively

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maciej KujawskiDepartment of Immunology and Theranostics, Beckman Research Institute, City of Hope, Duarte, California.
Eric AniogoDepartment of Immunology and Theranostics, Beckman Research Institute, City of Hope, Duarte, California.
Patty WongDepartment of Radiation Oncology, Beckman Research Institute and Medical Center, City of Hope, Duarte, California; and.
Susanta HuiDepartment of Radiation Oncology, Beckman Research Institute and Medical Center, City of Hope, Duarte, California; and.
Hemendra GhimireDepartment of Radiation Oncology, Beckman Research Institute and Medical Center, City of Hope, Duarte, California; and.
Erasmus K PokuDepartment of Radiopharmacy, Beckman Research Institute, City of Hope, Duarte, California.
Paul J YazakiDepartment of Immunology and Theranostics, Beckman Research Institute, City of Hope, Duarte, California.
Jeffrey Y C WongDepartment of Radiation Oncology, Beckman Research Institute and Medical Center, City of Hope, Duarte, California; and.
John E ShivelyDepartment of Immunology and Theranostics, Beckman Research Institute, City of Hope, Duarte, California; jshively@coh.org.

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
Targeted radiation and immunocytokine therapy for CEA positive malignanciesR01CA283603 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI John Ernest Shively, JEFFREY Y WONG · 2023 to 2026
$2.7M
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA283603
6 · The paper itself

Abstract

The rationale of this study was to evaluate the efficacy of 3 types of targeted therapy for solid tumors, comprising image-guided radiation therapy (IGRT), low-dose targeted α-therapy (TAT), and antibody-targeted interleukin-2 immunocytokine therapy, with the expectation that the combination of 2 types of targeted radiation therapy would perform better than either monotherapy with immunocytokine therapy.

Indexed as

Alpha ParticlesColonic NeoplasmsImmunotherapyMolecular Targeted TherapyRadiotherapy, Image-GuidedAnimalsBreast NeoplasmsCarcinoembryonic AntigenCell Line, TumorCombined Modality TherapyFemaleInterleukin-2MicePositron-Emission TomographyCarcinoembryonic AntigenInterleukin-2image-guided radiotherapyradioimmunoimagingradionuclide therapytargeted immunotherapytargeted α-therapy

Identifiers

PMID40813233
PMCPMC12487870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.