Evidence map›Paper›PMID 40812804›Full record

ArticleBMJ open2025

Effect of intraoperative oesophageal pressure-guided PEEP on postoperative pulmonary complications in elderly patients undergoing major laparoscopic surgery: study protocol for a multicentre randomised controlled clinical trial in China.

Jing Zhong, Peiyao Xu, Xiushi Zhou, Kefeng Zou, Jian Yu, Yujia Liu, Min Zhu, Mengping Wei, Haokang Yang, Changhong Miao

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06150079 (Effect of Individualized PEEP Titration on Postoperative Pulmonary Complications in Elderly Patients Undergoing Major Laparoscopic Surgery- A Multicenter Randomized Controlled Clinical Trial), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06150079 nacompletednot on this map

Effect of Individualized PEEP Titration on Postoperative Pulmonary Complications in Elderly Patients Undergoing Major Laparoscopic Surgery- A Multicenter Randomized Controlled Clinical Trial

TypeinterventionalSponsorShanghai Zhongshan HospitalRan2023 to 2025Enrolled240ConditionsPostoperative Pulmonary Complications, Positive End-expiratory Pressure, Elderly, Laparoscopic SurgeryArmsPes-Guided PEEP titration
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jing Zhong *Department of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-8764-0187
Peiyao Xu *Department of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China.ORCID http://orcid.org/0009-0002-9495-0252
Xiushi Zhou *Department of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0003-4388-6369
Kefeng Zou *Department of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China.ORCID http://orcid.org/0009-0000-6387-7502
Jian YuDepartment of Anesthesiology, Shanghai Geriatric Medical Center, Shanghai, China.ORCID http://orcid.org/0009-0004-8197-6845
Yujia LiuDepartment of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0003-4163-7940
Min ZhuDepartment of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China.
Mengping WeiDepartment of Anesthesiology, Zhongshan Hospital Fudan University Xiamen Branch, Xiamen, China.ORCID http://orcid.org/0009-0005-8289-9527
Haokang YangShanghai Medical School, Fudan University, Shanghai, China.ORCID http://orcid.org/0009-0008-5452-0577
Changhong MiaoDepartment of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China ziteng1934@aliyun.com.ORCID http://orcid.org/0000-0002-3406-8877

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPostoperative pulmonary complications (PPCs) induced by mechanical ventilation in general anaesthesia are related to poor clinical outcomes. Positive end-expiratory pressure (PEEP) is a key component of the lung protective ventilation strategy. Individualised PEEP guided by end-expiratory oesophageal pressure (Pes) to maintain a positive end-expiratory transpulmonary pressure can avoid alveolar collapse and improve the respiratory mechanics. However, there is no research studying the relationship between the Pes-guided PEEP titration and PPCs. The aim of our study is to investigate the potential role of Pes-guided PEEP titration on the incidence of PPCs and respiratory mechanics. METHODS AND ANALYSIS: A total of 232 elderly patients undergoing major laparoscopic surgery under general anaesthesia will be recruited in four tertiary teaching hospitals in China. Patients will be randomly allocated to the control group (PEEP set at 3 cm H ETHICS AND DISSEMINATION: The study has received ethics approval from the ethics committee of the Zhongshan Hospital, Fudan University (China) with the approval number B2023-334R. The results of the study will be submitted for publication in peer-reviewed journals. PROTOCOL VERSION: Version 1, on 9 October 2023. TRIAL REGISTRATION NUMBER: NCT06150079.

Indexed as

Intraoperative CareLaparoscopyLung DiseasesPositive-Pressure RespirationPostoperative ComplicationsAgedChinaFemaleHumansMaleMulticenter Studies as TopicRandomized Controlled Trials as TopicAdult anaesthesiaAdult surgeryFrail ElderlyProtocols & guidelinesRandomized Controlled TrialRespiratory physiology

Identifiers

PMID40812804
PMCPMC12352154

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.