Evidence map›Paper›PMID 40812542›Full record

ArticleThe journal of pain2025

Associations between pain experiences and gray matter volume in youth in the adolescent brain cognitive development (ABCD) study.

Carmen I Bango, Scott A Jones, Sara Shao, Dani Y Del Rubin, Arturo Lopez Flores, Bonnie J Nagel, Amy L Holley, Anna C Wilson

Abstract read
In one paragraph

Article in The journal of pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carmen I BangoDepartment of Psychiatry, Oregon Health & Science University, Portland, OR, United States; Department of Pediatrics, Institute on Development and Disability, Oregon Health & Science University, Portland, OR, United States. Electronic address: bango@ohsu.edu.
Scott A JonesDepartment of Psychiatry, Oregon Health & Science University, Portland, OR, United States; Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, United States.
Sara ShaoDepartment of Psychiatry, Oregon Health & Science University, Portland, OR, United States; Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, United States.
Dani Y Del RubinDepartment of Psychiatry, Oregon Health & Science University, Portland, OR, United States; Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, United States.
Arturo Lopez FloresDepartment of Psychiatry, Oregon Health & Science University, Portland, OR, United States.
Bonnie J NagelDepartment of Psychiatry, Oregon Health & Science University, Portland, OR, United States; Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, United States; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States.
Amy L HolleyDepartment of Pediatrics, Institute on Development and Disability, Oregon Health & Science University, Portland, OR, United States.
Anna C WilsonDepartment of Pediatrics, Institute on Development and Disability, Oregon Health & Science University, Portland, OR, United States.

Funding

A Prisma Upgrade for the OHSU Advanced Imaging Research Center 3T MRI InstrumentS10OD021701 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROONEY, WILLIAM D · 2016 to 2016
$1.6M
Neurobiology of pain experiences in youth in the ABCD studyR21HD112210 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILSON, ANNA CAMILLE · 2022 to 2022
$424k
32-Channel Head Coil and Hardware Upgrade for 3T Magnetom Trio A Tim InstrumentS10OD016356 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROONEY, WILLIAM D · 2014 to 2014
$115k
NICHD NIH HHS R21 HD112210NIH HHS S10 OD016356NIH HHS S10 OD021701
6 · The paper itself

Abstract

Pain in youth is a growing public health concern. While research suggests pervasive differences in brain morphology with pain in adulthood, this relationship is less studied in adolescence. To address this gap, the present study explored pain-related associations with gray matter volume across 82 brain regions in a community sample of 7712 youth (mean age = 11.96) by comparing structural brain measures between those with (n = 2668; 34.6%) and without (n = 5044; 65.4%) past-month pain and examining associations with a continuous latent pain factor composed of average pain ratings, worst pain ratings, and pain limitations. Results showed no significant morphological differences between groups with and without past-month pain. Among participants reporting pain, average pain limitations were generally low, despite varied pain intensity, duration, and number of pain locations. Within this group, higher latent pain scores were associated with lower gray matter volume in six cortical regions (bilateral precentral, right postcentral, right inferior parietal, left supramarginal and left lateral occipital gyri; all p

Indexed as

Adolescent DevelopmentBrainCerebral CortexGray MatterPainAdolescentChildFemaleHumansMagnetic Resonance ImagingMalePain MeasurementABCD studyGray matter volumeMagnetic resonance imagingPainYouth

Identifiers

PMID40812542
PMCPMC12403542

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.