ArticleInternational dental journal2025
Microbiome Shifts in Peri-Implantitis: Longitudinal Characterization of Dysbiosis and Resolution.
Article in International dental journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Metagenome and Metabolic Pathways in Plaque Biofilms of Thai ELANE-Associated Neutropenic Patients: An Original Study and Scoping Review.European journal of dentistry · 2026Article
- Dual-function thermoresponsive antibiotic-loaded hydrogel with antimicrobial and osteogenic properties for implant-related infection control.Bioactive materials · 2026Article
- The Role of Biologically Active Materials in Peri-Implant Diseases.Journal of clinical medicine · 2026Review
- Shotgun metagenomic profiling reveals ecological and functional alterations of the oral microbiome in craniosynostosis.Journal of oral microbiology · 2026Article
- Research advances in early diagnosis and treatment strategies for peri-implantitis: from microecology to regenerative therapy.Frontiers in cellular and infection microbiology · 2026Review
- Peri-implantitis biofilm from explanted implants in Korean patients: microbial and functional profiling.Frontiers in cellular and infection microbiology · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo characterize the longitudinal dynamics of the peri-implant microbiome in patients with peri-implantitis and healthy implants.
methodsThe peri-implant microbiome was characterized longitudinally in patients with peri-implantitis and healthy implants via 16S rRNA gene sequencing. Samples were collected at baseline, 3-, and 6-months post-treatment. Bioinformatic analysis was performed to identify significant microbial shifts over time
resultsAt baseline, peri-implantitis sites exhibited significantly higher relative abundances of Prevotella (8.44%) and Fusobacterium (16.91%), compared to healthy implant sites, which were dominated by Streptococcus (16.91%) and Neisseria (10.06%). Post-treatment, Haemophilus increased in both groups by 3 months, particularly in peri-implantitis sites (19.94%). At 6 months, Streptococcus increased in PI sites (13.10%), while Veillonella and Neisseria remained prevalent in healthy sites. Differential abundance analysis confirmed partial recovery of peri-implantitis sites, with baseline dysbiosis marked by increased Veillonella, Treponema denticola, and Porphyromonas gingivalis.
conclusionsThis study highlights dynamic shifts in the peri-implant microbiome during peri-implantitis progression and recovery, marked by specific changes in Prevotella, Fusobacterium, Haemophilus, Streptococcus, Veillonella, and key periodontal pathogens. These longitudinal changes offer insights into disease pathogenesis and underscore the potential of microbiome-targeted therapies.
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