Hepatic uptake of estradiol-3-glucuronide and estradiol-3-sulfate-17β-glucuronide by human organic anion transporting polypeptides 1B1, 1B3, and 2B1.

Lanjing Li, Ru Huan, Ting Liang, Han Liu, Yao Dong, Shuang Chen, Chen Zhang, Chunshan Gui

Abstract read

In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lanjing LiCollege of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.

Ru HuanCollege of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.

Ting LiangCollege of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.

Han LiuCollege of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.

Yao DongCollege of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.

Shuang ChenCollege of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.

Chen ZhangCollege of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.

Chunshan GuiCollege of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China. Electronic address: guichunshan@suda.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Estradiol is the most potent and biologically active form of estrogen, with glucuronide as its predominant conjugation form. Major estradiol glucuronides include estradiol-3-glucuronide (E

Indexed as

EstradiolLiverLiver-Specific Organic Anion Transporter 1Organic Anion TransportersSolute Carrier Organic Anion Transporter Family Member 1B3ATP Binding Cassette Transporter, Subfamily G, Member 2Biological TransportGlucuronidesHEK293 CellsHepatocytesHumansMultidrug Resistance-Associated Protein 2Neoplasm ProteinsABCC2 protein, humanABCG2 protein, humanATP Binding Cassette Transporter, Subfamily G, Member 2Estradiolestradiol-17 beta-glucuronideGlucuronidesLiver-Specific Organic Anion Transporter 1Multidrug Resistance-Associated Protein 2Neoplasm ProteinsOrganic Anion TransportersSLCO1B1 protein, humanSLCO1B3 protein, humanSLCO2B1 protein, humanSolute Carrier Organic Anion Transporter Family Member 1B3Estradiol glucuronideHepatic transporterLiquid chromatography-tandem mass spectrometryOrganic anion transporting polypeptideSelective substrate

Identifiers

PMID40811889

DOI10.1016/j.dmd.2025.100132

PMCPMC12597597

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.