Trial report in JCO oncology practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Emi H CaywoodNemours Children's Hospital, Delaware, Lisa Dean Moseley Foundation Institute for Cancer and Blood Disorders, Wilmington, DE.ORCID 0000-0002-2873-6058
Nicole Crellin-ParsonsProgram in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0009-0009-2835-1594
Jenna DemedisCenter for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO.ORCID 0000-0001-5191-7511
David DickensDepartment of Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, IA.ORCID 0000-0001-8821-6022
Adam J EsbenshadeDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-0154-4996
David R FreyerCancer and Blood Disease Institute, Children's Hospital Los Angeles/Department of Pediatrics, Keck School of Medicine, University of Southern CA, Los Angeles, CA.ORCID 0000-0001-5280-990X
Allison C GrimesPediatric Hematology Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX.ORCID 0000-0001-5729-2778
Kara M KellyDepartment of Pediatrics, Roswell Park Comprehensive Cancer Center, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY.ORCID 0000-0003-1473-3937
Allison A KingDivision of Public Health Sciences, Washington University School of Medicine, St Louis, MO.ORCID 0000-0002-1951-6176
Lisa M KlesgesDivision of Public Health Sciences, Washington University School of Medicine, St Louis, MO.ORCID 0000-0001-6237-4743
Etan OrgelCancer and Blood Disease Institute, Children's Hospital Los Angeles/Department of Pediatrics, Keck School of Medicine, University of Southern CA, Los Angeles, CA.ORCID 0000-0002-1487-6818
Andrea D OrseyCenter for Cancer and Blood Disorders, Connecticut Children's Medical Center, Hartford, CT.
Michael E RothDepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0002-6411-8353
Farha SheraniDriscoll Children's Hospital, Cancer and Blood Disorders Center and Texas A&M University, Corpus Christi, TX.
Emily VetteseProgram in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada.
Alexandra WalshCenter for Cancer and Blood Disorders, Phoenix Children's Hospital, Thomas Campus, Phoenix, AZ.ORCID 0000-0001-6261-8357
Wendy Woods-SwaffordBlank Cancer and Blood Disorders Center, Blank Children's Hospital-UnityPoint Health, Des Moines, IA.ORCID 0000-0002-6280-5360
Lolie C YuLouisiana State University Health Sciences Center/Children's Hospital, New Orleans, LA.
George A TomlinsonDepartment of Medicine, Toronto General Hospital, Toronto, ON, Canada.ORCID 0000-0002-9328-6399
Lillian SungProgram in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0003-0951-3091
Funding
Symptom Screening Linked to Care Pathways for Children with Cancer: a Cluster Randomized TrialR01CA251112 · NCI · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI DUPUIS, LAURA LEE, GRIMES, ALLISON · 2020 to 2024
$2.3M
NCI NIH HHS R01 CA251112
6 · The paper itself
Abstract
purposeThe objective was to identify factors associated with self-reported symptom burden measured using Symptom Screening in Pediatrics Tool (SSPedi) in pediatric patients with cancer.
methodsThis was a secondary analysis of a cluster randomized trial enrolling pediatric patients newly diagnosed with cancer. Twenty sites were randomized to routine symptom screening versus usual care. Intervention included thrice-weekly symptom screening with SSPedi, delivery of severely bothersome scores to health care teams, and implementation of locally adapted symptom management care pathways. Primary outcome was total SSPedi scores, 0 (no bothersome symptoms) to 60 (worst bothersome symptoms), obtained at baseline, week four, and week eight in 430 patients (n = 217 intervention and n = 213 usual care). We created a mixed linear regression model evaluating design (including time point), patient/guardian, and site characteristics for their associations with symptom burden after controlling for treatment assignment.
resultsSSPedi scores were significantly lower at weeks 4 and 8 compared with baseline (
conclusionTotal symptom burden was reduced by time, intervention (symptom screening and care pathways), and greater physician staffing ratio. Females had higher symptom burden. These data may inform programmatic implementation of routine symptom screening in pediatric patients with cancer.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Factors Associated With Symptom Burden Among Pediatric Patients With Cancer. · full record | OpenQuestion