Evidence map›Paper›PMID 40811667›Full record

Trial reportThe Journal of infectious diseases2026

Cytokines Associated With Moderate and Severe Adverse Events During a Sporozoite Malaria Vaccine Trial With Controlled Human Malaria Infection.

Lauren P Jatt, Kevin M Gillespie, Phuong Van, Stephen L Hoffman, Lisa A Jackson, Sean C Murphy, James R Heath, James G Kublin

Abstract readClinical Trial, Phase IRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lauren P JattVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0001-7034-9046
Kevin M GillespieVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Phuong VanVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Stephen L HoffmanSanaria Inc., Rockville, Maryland.
Lisa A JacksonKaiser Permanente Washington Health Research Institute, Seattle, Washington.
Sean C MurphyDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington.ORCID 0000-0002-2048-0131
James R HeathInstitute for Systems Biology, Seattle, Washington.ORCID 0000-0001-5356-4385
James G KublinVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0003-1279-3741

Funding

HOST DEFENSE TRAINING IN ALLERGY AND INFECTIOUS DISEASEST32AI007044 · NIAID · UNIVERSITY OF WASHINGTON · PI DAVID Neal FREDRICKS · 1985 to 2026
$14.6M
National Institute of Allergy and Infectious Diseases of the National Institutes of Health 5T32AI007044National Institute of Allergy and Infectious Diseases of the National Institutes of Health DMID 11-0042NIAID NIH HHS HHSN272201300019CNIAID NIH HHS HHSN272201300019INIAID NIH HHS T32 AI007044
6 · The paper itself

Abstract

Ensuring the safety and efficacy of candidate vaccines is critical. Although mechanisms underpinning protective immune responses to malaria vaccines are frequently investigated, immune responses correlating with moderate and severe adverse events (AEs) are rarely examined. Here, we leverage a malaria vaccine trial with a higher-than-expected AE rate and frequent sampling to investigate cytokine profiles associated with AEs. We found that Interleukin-6 was elevated on days in which individuals experienced moderate and severe AEs. More research on immune responses associated with AEs is warranted in order to identify biomarkers associated with systemic reactogenicity and accelerate vaccine development.

Indexed as

CytokinesMalariaMalaria, FalciparumMalaria VaccinesSporozoitesAdolescentAdultBiomarkersFemaleHumansInterleukin-6MalePlasmodium falciparumYoung AdultBiomarkersCytokinesInterleukin-6Malaria Vaccinesadverse eventscontrolled human malaria infectioncytokineIL-6vaccine

Identifiers

PMID40811667
PMCPMC13381272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.