ArticleScience (New York, N.Y.)2025
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA.
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Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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19 citing papers in PubMed.
- Reappraising the topology of cell-free fetal DNA in maternal blood toward improved prenatal genetic diagnostics.Science advances · 2026Review
- Megakaryocytes Internalize and Are Activated by Immune Complexes.Circulation research · 2026Article
- Tumor-educated platelets in cancer diagnostics and prognostics: A critical appraisal and roadmap for clinical translation.International journal of cancer · 2026Review
- A nucleic acid labeling chemistry reveals surface DNA on exosomes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Large-Scale Quantitative Morphometry of Platelet α-Granules via SIM Super-Resolution Microscopy for Cancer Liquid Biopsy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Profiling KRAS mutations in whole blood by error-corrected maximum depth sequencing.NPJ precision oncology · 2026Article
- Platelets Outperform Leukocytes in Transcriptomic Liquid Biopsy Profiling of Myeloproliferative Neoplasms.bioRxiv : the preprint server for biology · 2026Article
- Emerging liquid biopsy tools to analyse cancer biomarkers: electrochemical sensors and extracellular vesicle analysis.Biochemical Society transactions · 2026Review
- Integrating inflammation-based scores into gastric cancer prognosis.World journal of gastrointestinal surgery · 2026Article
- Thrombocytosis in cancer patients: when more is not better-in fact, the opposite.Cancer metastasis reviews · 2026Review
- From escort to target, the multidimensional roles and prospects of platelets in tumor immune checkpoint inhibitor therapy.Frontiers in immunology · 2026Review
- Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review).Oncology reports · 2026Review
- Non-coding RNAs in tumor-educated platelets: emerging roles in cancer progression, biomarker discovery, and therapeutic targeting.Frontiers in oncology · 2026Review
- Review
- A nucleic acid labeling chemistry reveals surface DNA on exosomes.bioRxiv : the preprint server for biology · 2025Article
- Network Controllability Reveals Key Mitigation Points for Tumor-Promoting Signaling in Tumor-Educated Platelets.International journal of molecular sciences · 2025Article
- DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells.bioRxiv : the preprint server for biology · 2025Article
- Fragmentomic-based algorithm to computationally predict tumor-somatic, germline, and clonal hematopoiesis variant origin in liquid biopsy.The journal of liquid biopsy · 2025Article
- Platelet Indices and ApoA1 as Predictive Markers in Neoadjuvant Immunochemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma: A Retrospective Study.Journal of inflammation research · 2025Article
Corrections and comments
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Authors and funding
33 authors.
Lauren MurphyMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR), Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.ORCID 0000-0001-9506-2762
Jeanne InchauspéMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR), Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.ORCID 0000-0003-4489-423X
Giampiero ValenzanoDepartment of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, UK.ORCID 0009-0000-4882-4066
Pamela HollandCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh BioQuarter, 4-5 Little France Drive, Edinburgh, UK.ORCID 0009-0008-8265-9808
Nikolaos SousosMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR), Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.ORCID 0000-0002-9100-2954
Hayley L Belnoue-DavisWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Rong LiMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR), Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.ORCID 0000-0002-1805-810X
Natalie J JoossMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR), Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.ORCID 0000-0002-2314-4993
Camelia BenlabiodMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR), Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.ORCID 0000-0001-7119-9326
Eleanor MurphyMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR), Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Zohar EtzioniLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-7172-4036
Emelie ShepherdLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Lucy DenlyLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0001-9915-4760
Sujata BiswasOxford University Hospitals NHS Foundation Trust, Oxford, UK.ORCID 0000-0002-0700-7286
Lin ChenLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Jennifer O'SullivanMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR), Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.ORCID 0000-0003-0502-7133
Michael P RimmerCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh BioQuarter, 4-5 Little France Drive, Edinburgh, UK.ORCID 0000-0002-3295-8753
Abdullah O KhanMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR), Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.ORCID 0000-0003-0825-3179
Christina Simoglou KaraliMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR), Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.ORCID 0000-0003-2169-6580
Nadia NasreddinWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID 0000-0002-3025-6213
Ian S HitchcockYork Biomedical Research Institute and Department of Biology, University of York, Heslington, York, UK.ORCID 0000-0001-7170-6703
Milka KoupenovaDivision of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, Massachusetts, USA.ORCID 0000-0001-5934-8990
Skirmantas KriaucionisLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-2273-5994
Jim R HughesMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR), Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Eric O'NeillDepartment of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, UK.ORCID 0000-0002-0060-6278
Manu VatishNuffield Department of Women's and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, UK.ORCID 0000-0002-6012-2574
Paul ReesDepartment of Biomedical Engineering, Faculty of Science and Engineering, Swansea University, Swansea, Wales, UK.ORCID 0000-0002-7715-6914
Simon LeedhamWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID 0000-0003-1476-6982
Michael DesboroughMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR), Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.ORCID 0000-0002-1951-5616
Adam J MeadMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR), Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.ORCID 0000-0001-8522-1002
Benjamin Schuster-BöcklerLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-8892-5133
Christopher D GregoryCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh BioQuarter, 4-5 Little France Drive, Edinburgh, UK.ORCID 0000-0002-7553-0132
Bethan PsailaMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR), Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.ORCID 0000-0001-8198-9663
Funding
Cancer Research UK 29034Cancer Research UK RCCSCF-MAY24/100001Medical Research Council MR/T04490X/1
Abstract
Platelets are anucleate blood cells vital for hemostasis and immunity. During cell death and aberrant mitosis, nucleated cells release DNA, resulting in "cell-free" DNA in plasma (cfDNA). An excess of cfDNA is deleterious. Given their ability to internalize pathogen-derived nucleic acids, we hypothesized that platelets may also clear endogenous cfDNA. We found that, despite lacking a nucleus, platelets contained a repertoire of DNA fragments mapping across the nuclear genome. We detected fetal DNA in maternal platelets and cancer-derived DNA in platelets from patients with premalignant and cancerous lesions. As current liquid biopsy approaches utilize platelet-depleted plasma, important genetic information contained within platelets is being missed. This study establishes a physiological role for platelets that has not previously been highlighted, with broad translational relevance.
Indexed as
Blood PlateletsCell-Free Nucleic AcidsCirculating Tumor DNADNA, NeoplasmFetusNeoplasmsFemaleFetal BloodFlow CytometryHumansLiquid BiopsyPregnancyCell-Free Nucleic AcidsCirculating Tumor DNADNA, Neoplasm
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.