Evidence map›Paper›PMID 40811503›Full record

ReviewCirculation research2025

Sleep Disruption and Atrial Fibrillation: Evidence, Mechanisms and Clinical Implications.

Abhishek Deshmukh, Naima Covassin, Yves Dauvilliers, Virend K Somers

Abstract readReview
In one paragraph

Review in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Sleep, Neural Circulatory Control, and Cardiovascular Disease: A Mechanistic Review.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abhishek DeshmukhDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (A.D., N.C., V.K.S.).ORCID 0000-0002-9560-1102
Naima CovassinDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (A.D., N.C., V.K.S.).ORCID 0000-0003-0523-3615
Yves DauvilliersDepartment of Neurology, Sleep-Wake Disorders Center, Gui-de-Chauliac Hospital, Centre Hospitalier Universitaire (CHU) Montpellier, Institute for Neurosciences of Montpellier Institut National de la Santé et de la Recherche Médicale (INSERM), University of Montpellier, France (Y.D.).ORCID 0000-0003-0683-6506
Virend K SomersDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (A.D., N.C., V.K.S.).ORCID 0000-0003-4045-4341

Funding

Disease Mechanisms in Sleep ApneaR01HL065176 · NHLBI · MAYO CLINIC ROCHESTER · PI SOMERS, VIREND K · 1999 to 2021
$5.8M
Sleep Apnea and Hypertrophic Cardiomyopathy - Implications for Arrhythmia and Sudden DeathR01HL134885 · NHLBI · MAYO CLINIC ROCHESTER · PI SOMERS, VIREND K · 2017 to 2020
$3.0M
NHLBI NIH HHS R01 HL065176NHLBI NIH HHS R01 HL134885
6 · The paper itself

Abstract

Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia, with its incidence rising due to aging populations, obesity, and advancements in diagnostic modalities. The interplay between sleep disorders and AF is increasingly recognized, with obstructive sleep apnea (OSA) serving as a well-established risk factor. However, emerging evidence implicates additional sleep disturbances-including central sleep apnea, insomnia, and restless legs syndrome-in AF pathogenesis and progression. Despite compelling observational data, interventional studies evaluating the impact of sleep disorder treatment on AF outcomes have yielded mixed results. Although continuous positive airway pressure therapy in patients with OSA mitigates AF recurrence, randomized controlled trials have yet to confirm a definitive causal benefit. This review synthesizes epidemiological, mechanistic, and interventional data linking sleep disorders to AF.

Indexed as

Atrial FibrillationSleepSleep Wake DisordersAnimalsContinuous Positive Airway PressureHumansRisk FactorsSleep Apnea, Obstructiveatrial fibrillationcontinuous positive airway pressureheart failuresleep apnea, centralsleep apnea, obstructive

Identifiers

PMID40811503
PMCPMC12352572

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.