Evidence map›Paper›PMID 40811477›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

A tubulin-MAPKKK pathway engages tubulin isotype interaction for neuroprotection.

Junxiang Zhou, Chihin Feng, Yue Sun, Kentaro Noma, Yishi Jin

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Junxiang ZhouDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0002-9166-3816
Chihin FengDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.
Yue SunDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.
Kentaro NomaDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0002-6487-8037
Yishi JinDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0002-9371-9860

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Molecular genetics of axon and synapse development and maintenanceR35NS127314 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yishi Jin · 2022 to 2026
$4.3M
NIH HHS P40 OD010440NINDS NIH HHS R35 NS127314UC | UCSD | Kavli Institute for Brain and Mind, University of California, San Diego (KIBM, UCSD) postdoc scholarship
6 · The paper itself

Abstract

The microtubule (MT) cytoskeleton is essential for neuronal morphology, neurite growth, synapse formation and maintenance, as well as regulation of signal transduction. Most cells express multiple isotypes of α- and β-tubulin that can coassemble into MTs. While a variety of signaling pathways regulate MT integrity and homeostasis, little is known about how tubulin isotypes interact in vivo. Here, we report a mechanism in which altered function of a neuronal β-tubulin in

Indexed as

Caenorhabditis elegans ProteinsMAP Kinase Kinase KinasesNeuroprotectionTubulinAnimalsCaenorhabditis elegansMicrotubulesNeuritesNeuronsSignal TransductionSynapsesCaenorhabditis elegans ProteinsDLK-1 protein, C elegansMAP Kinase Kinase KinasesTubulinbZip protein CEBP-1DLK kinasemicrotubule plasticityneuronal resiliencetubulin isotype

Identifiers

PMID40811477
PMCPMC12403078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.