Evidence map›Paper›PMID 40811476›Full record

ArticlePloS one2025

Hypogonadism and its associated factors among adult male type 2 diabetes mellitus patients at the university of gondar comprehensive specialized hospital, Northwest Ethiopia 2024: A comparative cross-sectional study.

Arega Zenaw, Elias Chane, Getnet Fetene, Habtamu Wondifraw, Amare Mekuanint, Yonatan Kinde, Temesgen Kassie, Kassaw Demeke, Alebachew Fasil, Abebaw Worede

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Arega ZenawDepartment of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.ORCID https://orcid.org/0009-0006-5244-8212
Elias ChaneDepartment of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.ORCID https://orcid.org/0000-0002-6570-3781
Getnet FeteneDepartment of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Habtamu WondifrawDepartment of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Amare MekuanintDepartment of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Yonatan KindeDepartment of clinical chemistry, School of Biomedical and Laboratory Science, college of medicine and health science, Debre Markos University, Debre Markos, Ethiopia.
Temesgen KassieDepartment of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Kassaw DemekeDepartment of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Alebachew FasilDepartment of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.ORCID https://orcid.org/0000-0002-7677-4454
Abebaw WoredeDepartment of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHypogonadism is an established complication in male patients with type 2 diabetes mellitus, potentially exacerbating metabolic dysregulation and impairing quality of life. Global studies have documented an elevated prevalence of hypogonadism among diabetic individuals. However, there remains a scarcity of data regarding the prevalence and contributing factors of hypogonadism in patients with type 2 diabetes mellitus in Ethiopia, particularly in the Gondar region. METHODS AND MATERIALS: This comparative cross-sectional study included 330 participants (165 with type 2 diabetes mellitus and 165 age-matched controls), selected via systematic random sampling from June 27 to August 20, 2024. Data were collected through structured questionnaires and 5 mL blood samples were obtained by laboratory technologist. Analysis using SPSS version 25 involved descriptive statistics, independent t-tests, and binary logistic regression to identify factors associated with hypogonadism, with significance set at p < 0.05.

resultThe mean age of participants was 57 ± 8.9 years in the type 2 diabetes mellitus (T2DM) group and 55 ± 8.6 years among controls. Hypogonadism was identified in 30.3% of individuals with T2DM, compared to 7.2% in the control group. Multivariable logistic regression revealed that T2DM, elevated fasting blood glucose, advancing age, dys-regulated high-density lipoprotein levels, and obesity were independently associated with increased odds of hypogonadism. CONCLUSION AND RECOMMENDATION: The prevalence of hypogonadism was markedly higher in individuals with type 2 diabetes mellitus compared to the control group, concomitant with a significantly lower mean testosterone level. Multivariate analyses identified fasting blood glucose, high-density lipoprotein levels, advanced age, the presence of diabetes, and obesity as independent risk factors for hypogonadism. Notably, modifiable factors such as obesity, in conjunction with key metabolic indicators, underscore potential targets for intervention to alleviate the burden of hypogonadism in diabetic patients.

Indexed as

Diabetes Mellitus, Type 2HypogonadismAdultAgedBlood GlucoseCross-Sectional StudiesEthiopiaHospitals, SpecialHumansMaleMiddle AgedPrevalenceRisk FactorsBlood Glucose

Identifiers

PMID40811476
PMCPMC12352672

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