In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Jaepyo JeonDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030.ORCID 0000-0002-0275-7395 Travis I MooreDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030.ORCID 0000-0002-8503-6023 Insuk SoDepartment of Physiology and Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.ORCID 0000-0003-2294-2050 Marc FreichelDepartment of General Pharmacology, Pharmakologisches Institut, Universität Heidelberg, Heidelberg D- 69120, Germany.ORCID 0000-0003-1387-2636 Veit FlockerziInstitute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, Homburg D- 66421, Germany.
Lutz BirnbaumerFaculty of Biomedical Sciences, Laboratory of Function and Pharmacology of Ion Channels, Institute of Biomedical Research, Catholic University of Argentina, Buenos Aires C1107AFF, Argentina.ORCID 0000-0002-0775-8661 Michael X ZhuDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030.ORCID 0000-0002-5676-841X Funding
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9MTransmembrane Signaling Mechanisms Involving TRP ChannelsZ01ES101684 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BIRNBAUMER, LUTZ · 2003 to 2008
$2.1MExcitatory neurotransmission by PTX-sensitive G proteinsR01NS092377 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHU, MICHAEL X · 2015 to 2019
$1.7MMolecular mechanism of acidotoxicity to neuronsR01NS102452 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHU, MICHAEL X · 2017 to 2021
$1.7MMolecular Mechanism of Brain Regulation of Chronic PainR01NS114716 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHU, MICHAEL X · 2020 to 2024
$1.2MMechanoregulation of the Leukocyte Specific Integrin LFA-1 by the Actin CytoskeletonK01HL143111 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MOORE, TRAVIS I · 2018 to 2022
$856kRegulatory mechanisms of lysosomal degradation in neurodegenerative diseaseR21NS125167 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHU, MICHAEL X · 2021 to 2021
$429kHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL143111HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS092377HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS102452HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS114716HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS125167Intramural NIH HHS Z01 ES101684NHLBI NIH HHS K01 HL143111NICHD NIH HHS P50 HD103555NIEHS Intramural Research Program Z01-ES-0101684NINDS NIH HHS R01 NS092377NINDS NIH HHS R01 NS102452NINDS NIH HHS R01 NS114716NINDS NIH HHS R21 NS125167
6 · The paper itselfAbstract
Transient Receptor Potential Canonical 4 (TRPC4) channels have been implicated in multiple neurological functions, including anxiety and sociability. TRPC4 variants were also found in patients with autism. However, the contributions of TRPC4 to neurodevelopment remain undefined. Here, we show that neurobehavioral deficits appear early in young TRPC4 knockout (
Indexed as
ActomyosinDendritesIntegrinsLimbic SystemTRPC Cation ChannelsAnimalsBehavior, AnimalCalciumHippocampusMaleMiceMice, KnockoutNeurogenesisNeuronsActomyosinCalciumIntegrinsTRPC4 ion channelTRPC Cation Channelsdendritic developmenthippocampusintegrinslimbic-related behaviormGluRs
Identifiers
PMID40811469
PMCPMC12377748
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