Evidence map›Paper›PMID 40811461›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Atomistic mechanisms of calcium permeation modulated by Q/R editing and selectivity filter mutations in GluA2 AMPA receptors.

Florian Heiser, Johann Biedermann, Ece Kuru, Andrew J R Plested, Han Sun

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Atomistic mechanisms of calcium permeation modulated by Q/R editing and selectivity filter mutations in GluA2 AMPA receptors.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Florian Heiser *Department of Cellular Biophysics, Institute of Biology, Humboldt-Universität zu Berlin, Berlin 10117, Germany.ORCID 0009-0002-6538-1898
Johann Biedermann *Department of Cellular Biophysics, Institute of Biology, Humboldt-Universität zu Berlin, Berlin 10117, Germany.ORCID 0000-0002-7542-1999
Ece KuruDepartment of Cellular Biophysics, Institute of Biology, Humboldt-Universität zu Berlin, Berlin 10117, Germany.
Andrew J R PlestedDepartment of Cellular Biophysics, Institute of Biology, Humboldt-Universität zu Berlin, Berlin 10117, Germany.ORCID 0000-0001-6062-0832
Han SunResearch Unit of Structural Chemistry & Computational Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin 13156, Germany.ORCID 0000-0002-1655-0838

Funding

Deutsche Forschungsgemeinschaft (DFG) 291198853Deutsche Forschungsgemeinschaft (DFG) 390688087
6 · The paper itself

Abstract

GluA2 is a key subunit of

Indexed as

CalciumMutationReceptors, AMPAAnimalsBinding SitesHEK293 CellsHumansMolecular Dynamics SimulationCalciumglutamate receptor ionotropic, AMPA 2Receptors, AMPAion binding sitesion channelsMD simulationspatch clamp electrophysiologypermeability

Identifiers

PMID40811461
PMCPMC12377769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.