ArticlePLoS biology2025
A model of early-life interactions between the gut microbiome and adaptive immunity provides insights into the ontogeny of immune tolerance.
Article in PLoS biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The Gut-Pancreas Axis in Type 1 Diabetes: Emerging Insights into Microbiota and Immune Interactions.International journal of molecular sciences · 2026Review
- The hallmarks of host-microbiome decoupling.Frontiers in microbiology · 2026Review
- Teaching right from wrong: Developing a model of early immune education.PLoS biology · 2025Article
- Operationalizing Team Science at the Academic Cancer Center Network to Unveil the Structure and Function of the Gut Microbiome.Journal of clinical medicine · 2025Review
- Antibodies in breast milk: Pro-bodies designed for healthy newborn development.Immunological reviews · 2024Review
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3 authors.
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Abstract
To achieve immune and microbial homeostasis during adulthood, the developing immune system must learn to identify which microbes to tolerate and which to defend against. How such 'immune education' unfolds remains a major knowledge gap. We address this gap by synthesizing existing literature to develop a mechanistic mathematical model representing the interplay between gut ecology and adaptive immunity in humans during early life. Our results indicate that the inflammatory tone of the microenvironment is the mediator of information flow from pre- to post-weaning periods. We evaluate the power of postnatal fecal samples for predicting immunological trajectories and explore breastfeeding scenarios when maternal immunological conditions affect breastmilk composition. Our work establishes a quantitative basis for 'immune education', yielding insights into questions of applied relevance.
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