ArticlePloS one2025
Dosimetry study of 3D-printed noncoplanar template-assisted CT-guided 125I seed implantation for the treatment of recurrent and metastatic tumors in the head and neck.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Seven-year follow-up demonstrating sustained survival followingOncology letters · 2026Article
- Initial observations on dose optimization inFrontiers in oncology · 2026Article
- Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRecurrent and metastatic tumors of the head and neck pose significant treatment challenges due to their proximity to critical structures and prior radiation exposure. This study aimed to evaluate the consistency between preoperative and postoperative dosimetric parameters in CT-guided 3D-printed noncoplanar template (3DPNCT)-assisted radioactive iodine-125 seed implantation (RISI).
methodsTwenty-six patients with recurrent or metastatic head and neck cancer were retrospectively analyzed. Gross tumor volume (GTV) coverage and dosimetric parameters such as D90 (dose covering 90% of the GTV), conformity index (CI), and homogeneity index (HI) were compared before and after implantation. The Shapiro-Wilk test was used to assess data normality.
resultsThere were no significant differences between pre- and postoperative D90, V100, V150, or CI values (P > 0.05). Bland-Altman analysis showed high agreement for key metrics.
conclusions3DPNCT-assisted RISI demonstrated accurate dose delivery and high reproducibility. This approach may enhance local control while minimizing radiation to organs at risk in complex head and neck anatomies. These results suggest that this technique has promising clinical applicability in complex head and neck cases; however, further validation through larger prospective studies is warranted to confirm long-term efficacy and safety.
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