Evidence map›Paper›PMID 40811216›Full record

ArticlePediatric pulmonology2025

Effectiveness of A Respiratory Care Protocol Including Less Invasive Surfactant Administration in ≥ 35 Weeks Gestational Age Infants.

Etze Chotzoglou, Arun Prasath, Riddhi Desai, Lebanon David, Nancy Ornelas, Patti Burchfield, Larry Steven Brown, David B Nelson, Venkatakrishna Kakkilaya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Etze ChotzoglouDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
Arun PrasathDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.ORCID 0000-0002-2804-9311
Riddhi DesaiDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
Lebanon DavidParkland Health and Hospital System, Dallas, Texas.
Nancy OrnelasParkland Health and Hospital System, Dallas, Texas.
Patti BurchfieldDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
Larry Steven BrownParkland Health and Hospital System, Dallas, Texas.
David B NelsonDepartment of Obstetrics & Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas.
Venkatakrishna KakkilayaDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

backgroundIn October 2018, a respiratory care protocol (RCP) including less invasive surfactant administration (LISA), was introduced for preterm infants admitted on continuous positive airway pressure (CPAP). STUDY

designWe compared respiratory care practices and outcomes of ≥ 35-week gestational age (GA) infants between a pre-RCP (Jan 2016 to September 2018) and a post-RCP cohort (Oct 2018 to Dec 2021). Infants requiring < 24 h of CPAP and diagnosed with meconium aspiration syndrome were excluded.

resultsOf the 260 infants meeting inclusion criteria, 126 belonged to the pre-RCP and 134 to post-RCP cohort. Compared to pre-RCP, a lower proportion of infants in the post-RCP received CPAP on admission but a higher proportion received surfactant therapy (8% vs 22%, p < 0.001). Notably, surfactant therapy was associated with lower FiO

conclusionsImplementing an RCP increased surfactant use with associated improvement in oxygenation but did not improve outcomes. Further studies are necessary to evaluate the role of LISA in ≥ 35-week GA infants.

Indexed as

Continuous Positive Airway PressurePulmonary SurfactantsRespiratory Distress Syndrome, NewbornRespiratory TherapyClinical ProtocolsFemaleGestational AgeHumansInfant, NewbornInfant, PrematureLength of StayMaleRespiration, ArtificialRetrospective StudiesTreatment OutcomePulmonary Surfactantslate pretermLISARDSsurfactantterm

Identifiers

PMID40811216
PMCPMC12352716

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.