Evidence map›Paper›PMID 40811033›Full record

ArticleJCI insight2025

Atrial fibroblast-derived macrophage migration inhibitory factor promotes atrial macrophage accumulation in postoperative atrial fibrillation.

Joshua A Keefe, Jose Alberto Navarro-Garcia, Shuai Zhao, Mihail G Chelu, Xander Ht Wehrens

Abstract read
In one paragraph

Article in JCI insight, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joshua A KeefeCardiovascular Research Institute.
Jose Alberto Navarro-GarciaCardiovascular Research Institute.
Shuai ZhaoCardiovascular Research Institute.
Mihail G CheluCardiovascular Research Institute.
Xander Ht WehrensCardiovascular Research Institute.

Funding

Mechanisms of Lamin A/C-mediated Cardiac Conduction DisordersR01HL166832 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Mihail Gabriel Chelu · 2024 to 2026
$1.9M
Role of inflammation in postoperative atrial fibrillationR01HL180477 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2025 to 2026
$1.5M
Macrophage-mediated interleukin-6 signaling drives ryanodine receptor 2 calcium leak in postoperative atrial fibrillationF30HL172431 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI KEEFE, JOSHUA ANTHONY · 2024 to 2025
$99k
NHLBI NIH HHS F30 HL172431NHLBI NIH HHS R01 HL166832NHLBI NIH HHS R01 HL180477
6 · The paper itself

Abstract

<br> New study: Blocking MIF protein prevents irregular heartbeats after surgery by reducing harmful immune cell buildup in the atria.

Indexed as

Atrial FibrillationHeart AtriaIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMacrophagesPostoperative ComplicationsAnimalsFibroblastsHumansMaleMiceIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMif protein, mouseArrhythmiasCardiologyImmunologyMacrophagesSurgery

Identifiers

PMID40811033
PMCPMC12487863

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.