Trial reportAnnals of medicine2025
Intraoperative low-dose esketamine on postoperative quality of recovery in patients undergoing open gynecologic surgery: a double-blinded, parallel-group, placebo- controlled trial.
Trial report in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Ketamine and esketamine for postoperative analgesia in gynaecological surgery.The Cochrane database of systematic reviews · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGynecologic laparotomy surgery often leads to moderate to severe pain. Effective analgesia is essential for patient postoperative recovery. We aimed to evaluate the effect of low-dose esketamine on quality of recovery when used as part of multimodal analgesia in patients undergoing open gynecologic surgery.
methods140 female patients undergoing gynecologic laparotomy under general anesthesia were randomly assigned to receive intraoperative infusion of either 0.25 mg/kg/h esketamine (study group) or an equivalent volume of normal saline (control group). The primary outcome was quality of recovery at 24 h postoperatively, assessed using the 40-item quality of recovery questionnaire (QoR-40). Secondary outcomes included morphine consumption, pain scores, functional outcomes, adverse events, postoperative depressive symptom, chronic pain, and health-related quality of life.
resultsThe global QoR-40 score at 24 h was not significantly different between the two groups [study group, 178 (165-186); control group, 175 (164-186); median difference, 2; 95% CI, -3 to 7;
conclusionsIntraoperative infusion of 0.25 mg/kg/h esketamine had no additional benefit on early quality of recovery when used as part of multimodal analgesic regimen in patients undergoing open gynecologic surgery. Future investigations are needed to determine the optimal dosing regimen and identify subgroups of gynecologic patients who would benefit most from esketamine.
trial registrationChinese Clinical Trial Registry; ChiCTR 2200061021.
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