Evidence map›Paper›PMID 40810890›Full record

Observational studyLa Radiologia medica2025

Efficacy and safety of CT-guided oxygen-ozone (O

Alberto Bellelli, Valerio D'Andrea, Matteo Pileri, Bruno Beomonte Zobel

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in La Radiologia medica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alberto BellelliDepartment of Diagnostic and Interventional Radiology, Fatebenefratelli San Pietro Hospital, Rome, Italy. abellelli@libero.it.
Valerio D'AndreaOperative Research Unit of Radiology and Interventional Radiology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128, Rome, Italy.
Matteo PileriOperative Research Unit of Radiology and Interventional Radiology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128, Rome, Italy.
Bruno Beomonte ZobelOperative Research Unit of Radiology and Interventional Radiology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOxygen-ozone (O MATERIALS AND

methodsWe conducted a single-center retrospective observational study of patients with LBP who underwent CT-guided O

resultsA total of 123 patients were included. The mean baseline VAS score for the entire cohort was 7.5 ± 1.2, which significantly decreased to 3.5 ± 1.5 following treatment (T = 43.74, p < 0.001). In Group A, the mean VAS decreased from 7.2 ± 1.3 to 3.8 ± 1.4; in Group B, from 7.8 ± 1.0 to 3.2 ± 1.3; and in Group C, from 8.0 ± 0.9 to 3.0 ± 1.2. ANOVA revealed significant differences in post-treatment VAS scores among groups (F = 27.36, p < 0.001). Tukey's HSD indicated significant differences between Groups A and B (p < 0.001) and A and C (p < 0.001), with no significant difference between Groups B and C (p = 0.247). Overall, 21.95% of patients experienced significant improvement (VAS reduction > 4 points), 57.72% had moderate improvement (VAS reduction 2-4 points), and 18.7% showed minimal improvement (VAS reduction ≤ 1 point). No complications were reported during or after the procedures.

conclusionThe findings strongly support the efficacy and safety of O

Indexed as

Low Back PainOxygenOzoneRadiography, InterventionalTomography, X-Ray ComputedAdultAgedFemaleHumansMaleMiddle AgedPain MeasurementRetrospective StudiesTreatment OutcomeOxygenOzoneCT-guided injectionFacet jointIntradiscal—minimally invasive spine interventionLow back pain (LBP)Oxgen–ozone (O2–O3) therapy

Identifiers

PMID40810890

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.