Evidence map›Paper›PMID 40810870›Full record

ReviewBiomedical microdevices2025

Microfluidic and lab-on-a-chip devices for detection and diagnosis of periprosthetic joint infections.

Luca Pellegrino, Alberto Bulgarelli, Cristina Belgiovine, Mattia Loppini, Roberto Rusconi

Abstract readReview
In one paragraph

Review in Biomedical microdevices, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luca PellegrinoDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072, Italy. luca.pellegrino@humanitasresearch.it.ORCID http://orcid.org/0000-0002-2529-3781
Alberto BulgarelliDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072, Italy.ORCID http://orcid.org/0009-0001-4637-1646
Cristina BelgiovineDepartment of Biology and Biotechnology, University of Pavia, Via Adolfo Ferrata 9, Pavia, 27100, Italy.ORCID http://orcid.org/0000-0002-6986-9594
Mattia LoppiniDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072, Italy.ORCID http://orcid.org/0000-0001-8569-0669
Roberto RusconiDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072, Italy.ORCID http://orcid.org/0000-0002-8385-9296

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periprosthetic joint infection (PJI) is a serious complication of prosthetic joint implantation, which poses a significant burden on both individuals and society. Effective treatment relies on the rapid identification of the underlying cause; however, the diagnosis of PJI remains challenging, inefficient, and time-consuming. Current detection protocols based on clinical signs and conventional cultures often fail to provide definitive results. Additionally, advanced molecular analyses of synovial fluid samples, while effective, require specialized personnel and are impractical for on-site applications. This review aims to highlight the potential of microfluidic and lab-on-a-chip technologies in enhancing the identification of PJI, offering a rapid and accurate diagnostic method.

Indexed as

Lab-On-A-Chip DevicesMicrofluidic Analytical TechniquesProsthesis-Related InfectionsHumansSynovial FluidBiosensorsMicrobial infectionsMicrofluidic devicesTotal hip arthroplasty

Identifiers

PMID40810870
PMCPMC12354561

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.