SynthesisEuropean journal of pediatrics2025
Normal ranges of tissue Doppler imaging echocardiographic parameters in healthy term and preterm newborns: a systematic review and meta-analysis.
Synthesis in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reference values for tissue Doppler imaging (TDI) parameters in neonates remain limited and are not consistently defined across gestational ages or postnatal periods. We conducted a systematic review and meta-analysis to define normal ranges for TDI-derived myocardial performance indices in healthy term and preterm newborns, stratified by gestational age (GA) and day of life (DOL). We searched MEDLINE, EMBASE, and CENTRAL up to April 2024 for observational studies reporting TDI measures in neonates grouped by GA (< 32, 32-36, ≥ 37 weeks) and DOL (≤ 7, > 7). Study quality was assessed using the checklist, and evidence certainty was evaluated with a modified GRADE approach. Thirty-five studies including 3747 neonates were included in the analysis, comprising 1635 term and 2112 preterm infants. We analyzed peak systolic (s'), early (e') and atrial (a') diastolic velocities, as well as isovolumic contraction and relaxation times, ejection time, and ventricular filling time. TDI parameters increased with GA and DOL, reflecting early postnatal hemodynamic changes.
conclusionThis meta-analysis provides robust, clinically relevant reference ranges for TDI parameters in neonates across gestational and postnatal ages, supporting their broader use in functional cardiac assessment and informing future research directions. WHAT IS KNOWN: • Tissue Doppler imaging (TDI) has been widely applied to assess myocardial function in neonates. Reference ranges for TDI parameters in newborns exist but are not uniformly established across gestational ages and postnatal days. Variations in myocardial velocities and cardiac cycle times are known to reflect developmental changes in cardiac function. WHAT IS NEW: • This systematic review and meta-analysis define comprehensive normal ranges for TDI velocities and cardiac cycle time intervals in healthy term and preterm newborns, stratified by gestational age and days of life. It highlights hemodynamic adaptations in early life and provides clinically relevant benchmarks for assessing neonatal cardiac function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.