Evidence map›Paper›PMID 40810772›Full record

ReviewDermatology and therapy2025

Skin-Directed Therapies in Mycosis Fungoides: An Update.

Maciej Tota, Magdalena Łyko, Piotr Misiąg, Julia Łacwik, Julia Laska, Karol Biliński, Julita Kulbacka, Alina Jankowska-Konsur

Abstract readReview
In one paragraph

Review in Dermatology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Overlapping Hyperpigmented and Poikilodermatous Mycosis Fungoides.Case reports in dermatological medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maciej TotaFaculty of Medicine, Wroclaw Medical University, Pasteura 1, 50-367, Wroclaw, Poland. maciej.tota@student.umw.edu.pl.ORCID http://orcid.org/0000-0002-5298-6479
Magdalena Łyko *University Centre of General Dermatology and Oncodermatology, Wroclaw Medical University, Borowska 213, 50-556, Wroclaw, Poland.
Piotr MisiągFaculty of Medicine, Wroclaw Medical University, Pasteura 1, 50-367, Wroclaw, Poland.
Julia ŁacwikFaculty of Medical Sciences in Zabrze, Medical University of Silesia, Poniatowskiego 15, 40-055, Katowice, Poland.
Julia LaskaFaculty of Medical Sciences in Zabrze, Medical University of Silesia, Poniatowskiego 15, 40-055, Katowice, Poland.
Karol BilińskiFaculty of Medicine, Wroclaw Medical University, Pasteura 1, 50-367, Wroclaw, Poland.
Julita KulbackaDepartment of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211a, 50-556, Wroclaw, Poland.
Alina Jankowska-KonsurUniversity Centre of General Dermatology and Oncodermatology, Wroclaw Medical University, Borowska 213, 50-556, Wroclaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mycosis fungoides (MF) is the most common subtype of cutaneous T cell lymphoma (CTCL), characterized by monoclonal proliferation of malignant T cells primarily involving the skin. The management of MF, especially in the early stages, involves skin-directed therapies (SDTs) to achieve disease control, alleviate symptoms, and enhance the quality of life (QoL). This review provides an updated overview of SDTs in MF treatment, including topical agents such as corticosteroids, retinoids, mechlorethamine, carmustine, imiquimod, as well as photodynamic therapy (PDT); phototherapy modalities including narrowband UVB (nb-UVB) and psoralen-UVA (PUVA); local radiotherapy; total skin electron beam radiotherapy (TSEBT) and total skin helical tomotherapy (TSHT). We review the indications, mechanisms of action, efficacy data, and adverse effect profiles associated with both established and emerging SDTs. Additionally, we present ongoing clinical trials evaluating emerging SDTs in the treatment of MF.

Indexed as

Cutaneous T cell lymphomaMycosis fungoidesPhotodynamic therapyPhototherapySkin-directed therapyTopicalTotal skin electron beam radiotherapy

Identifiers

PMID40810772
PMCPMC12454724

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.