ArticleAntimicrobial agents and chemotherapy2025
Towards precision dosing of vancomycin in patients with allogeneic hematopoietic stem cell transplantation: a comparison of published population pharmacokinetic models.
Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Cystatin C-based eGFR better predicts renal vancomycin clearance than creatinine-based eGFR in patients with allogeneic stem cell transplantation.Clinical pharmacology and therapeutics · 2026Article
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5 authors.
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Abstract
Patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) often receive vancomycin as antibiotic treatment using therapeutic drug monitoring (TDM). TDM can be performed using a Bayesian approach, where concentration measurements are supported by a previously developed pharmacokinetic model based on a population as similar as possible to the treated patient. As a model developed in a similar population is not always available, it must be ensured that the predictive performance is not compromised. We retrospectively collected data from 121 adult allo-HSCT patients who received vancomycin treatment including trough concentration TDM between January and December 2021. Predictive performance of 21 published pharmacokinetic models was assessed by comparing the third observed vancomycin concentration per patient with the corresponding model prediction. Prediction was based on covariates alone (
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