Evidence map›Paper›PMID 40810663›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Bacteria-Targeted Single-Atom Nanozyme With Photothermal-Augmented Multi-Enzymatic Cascade and NO Delivery for Enhanced Infected Wound Healing.

Junyang Chen, Qing Chen, Xudong Qin, Haixia Yang, Xin Wang, Jianliang Zhou, Ying-Wei Yang, Jian Tian

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junyang ChenDepartment of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, P. R. China.
Qing ChenDepartment of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, P. R. China.
Xudong QinDepartment of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, P. R. China.
Haixia YangDepartment of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, P. R. China.
Xin WangCollege of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
Jianliang ZhouDepartment of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, P. R. China.
Ying-Wei YangCollege of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.ORCID https://orcid.org/0000-0001-8839-8161
Jian TianDepartment of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, P. R. China.

Funding

Bethune Medical Department of Jilin University "Leading the Charge with Open Competition" 2022JBGS04General Project of the Joint Fund for Translational Medicine and Interdisciplinary Research of Zhongnan Hospital of Wuhan University ZNJC202423National Natural Science Foundation of China 22271222National Natural Science Foundation of China 82270382Natural Science Foundation of Jilin Province 20230101052JCWuhan Talent Industry Leading Talent Project WHYCCYLJ2021002
6 · The paper itself

Abstract

Infected diabetic wound management confronts significant challenges, including bacterial resistance, oxidative stress, and impaired vascular repair, resulting in substantial unmet clinical needs. To address these issues, a multifunctional therapeutic nanoplatform, mCu-SAE@BNN6@PEG-Van (CBPV), is developed by sequentially functionalizing mesoporous copper single-atom nanozymes (mCu-SAE) loaded with the nitric oxide (NO) donor BNN6 and vancomycin-conjugated polyethylene glycol (PEG-Van). CBPV integrates three synergistic therapeutic modalities: 1) pathogen-specific targeting via Van-mediated bacterial recognition; 2) NIR-II photothermally enhanced catalytic therapy via Cu-N

Indexed as

Nitric OxidePhotothermal TherapyWound HealingWound InfectionAnimalsAnti-Bacterial AgentsCopperHumansMiceAnti-Bacterial AgentsCopperNitric Oxideantibacterial materialsbiomaterialsnanoplatformnanozymesphotothermal therapywound healing

Identifiers

PMID40810663
PMCPMC12622438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.