Evidence map›Paper›PMID 40810631›Full record

ArticlePhysiological reports2025

Conditional neuronal deletion of microRNA-141/200c cluster, but not microRNA-181a/b-1 cluster, is protective against experimental stroke in male mice.

Lijun Xu, Brian Griffiths, Xiaoyun Sun, Majesty Greer, Heather Chang, Elijah McMillin, Elizabeth Manis, Isabella Russo, Claire Ai Jue Dean, Creed M Stary

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lijun XuDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, School of Medicine, Palo Alto, California, USA.
Brian GriffithsDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, School of Medicine, Palo Alto, California, USA.
Xiaoyun SunDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, School of Medicine, Palo Alto, California, USA.
Majesty GreerDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, School of Medicine, Palo Alto, California, USA.
Heather ChangDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, School of Medicine, Palo Alto, California, USA.
Elijah McMillinDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, School of Medicine, Palo Alto, California, USA.
Elizabeth ManisDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, School of Medicine, Palo Alto, California, USA.
Isabella RussoDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, School of Medicine, Palo Alto, California, USA.
Claire Ai Jue DeanDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, School of Medicine, Palo Alto, California, USA.
Creed M StaryDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, School of Medicine, Palo Alto, California, USA.ORCID 0000-0001-9876-6634

Funding

Non-coding RNA regulation of sex differences in strokeR01NS107445 · NINDS · STANFORD UNIVERSITY · PI STARY, CREED MICHAEL · 2019 to 2023
$1.8M
American Heart Association (AHA) 18POST33990395HHS | National Institutes of Health (NIH) R01NS107445NINDS NIH HHS R01 NS107445
6 · The paper itself

Abstract

MicroRNAs (miRs) regulate the translation of target genes often in a cell-type specific manner. We previously demonstrated that downregulation of either miR-181a or miR-200c with intracranial injection of an inhibitor is protective against experimental stroke in mice. Here, we generated genetic lines of inducible Ca

Indexed as

Infarction, Middle Cerebral ArteryMicroRNAsNeuronsStrokeAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Gene DeletionMaleMiceMice, TransgenicCalcium-Calmodulin-Dependent Protein Kinase Type 2MicroRNAsMirn141 microRNA, mousemirn181 microRNA, mouseMirn200 microRNA, mousecell typeCKIIαMCAOmiRmiRNA

Identifiers

PMID40810631
PMCPMC12351801

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.