Evidence map›Paper›PMID 40810551›Full record

ArticleMicrobiology spectrum2025

Altered microRNA expression correlates with reduced TLR2/4-dependent periodontal inflammation and bone resorption induced by polymicrobial infection.

Syam Jeepipalli, Parvathi Gurusamy, Ana Rafaela Luz Martins, Eduardo Colella, Sandhya R Nadakuditi, Tushar Desaraju, Ashitha Yada, Jennifer Onime, John T William, Indraneel Bhattacharyya and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Syam JeepipalliDepartment of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-2769-8619
Parvathi GurusamyDepartment of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA.
Ana Rafaela Luz MartinsDepartment of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA.
Eduardo ColellaDepartment of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA.
Sandhya R NadakuditiDepartment of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA.
Tushar DesarajuDepartment of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA.
Ashitha YadaDepartment of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA.
Jennifer OnimeDepartment of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA.
John T WilliamDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, USA.
Indraneel BhattacharyyaDepartment of Oral and Maxillofacial Diagnostic Sciences, College of Dentistry, University of Florida, Gainesville, Florida, USA.
Edward K L ChanDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, USA.
L KesavaluDepartment of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-8828-8656

Funding

Dominant microRNAs as biomarkers in innate immunity and periodontitisR01DE028536 · NIDCR · UNIVERSITY OF FLORIDA · PI LAKSHMYYA, KESAVALU NAIDU · 2020 to 2024
$1.9M
NIDCR NIH HHS R01 DE028536
6 · The paper itself

Abstract

Periodontitis (PD) is a polymicrobial dysbiotic immuno-inflammatory disease. Toll-like receptors (TLRs) are present on gingival epithelial cells and recognize pathogen-associated molecular patterns on pathogenic bacteria, inducing the secretion of proinflammatory cytokines and initiating innate and adaptive antigen-specific immune responses to eradicate the invading microbes. Since PD is a chronic inflammatory disease, TLR2/TLR4 play a vital role in disease pathogenesis and in maintaining the periodontium during health. Many factors modulate the TLR-mediated signaling pathway, including specific microRNAs (miRNAs). The present study was designed to characterize the function of TLR2/4 signaling in the miRNA profile after polybacterial infection with IMPORTANCE: Periodontitis is the most prevalent chronic immuno-infectious multispecies dysbiotic disease of the oral cavity. The Toll-like receptors (TLRs) provide the first line of defense, one of the best-characterized pathogen detection systems, and play a vital role in recognizing multiple microbial products. Multispecies infection with periodontal bacteria

Indexed as

Bone ResorptionCoinfectionMicroRNAsPeriodontitisToll-Like Receptor 2Toll-Like Receptor 4AnimalsDisease Models, AnimalFusobacterium nucleatumMaleMiceMice, Inbred C57BLMice, KnockoutPorphyromonas gingivalisSignal TransductionTreponema denticolaMicroRNAsTlr2 protein, mouseTlr4 protein, mouseToll-Like Receptor 2Toll-Like Receptor 4microRNAsoral bacteriaperiodontal diseasepolymicrobial infectionToll-like receptors

Identifiers

PMID40810551
PMCPMC12502665

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.