Evidence map›Paper›PMID 40810484›Full record

ReviewGut microbes2025

Commensal bacterial glycosylation at the interface of host-bacteria interactions.

Chao Lei, Ting Wang, Jingzhi Wang, Yi Tan, Zhongbin Deng

Abstract readReview
In one paragraph

Review in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. α2-3-Sialylated Glycoproteins AttenuateInternational journal of molecular sciences · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Non-Malignant Granulocyte and Monocyte Disorders: An Update.British journal of biomedical science · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chao LeiDepartment of Surgery, Division of Immunotherapy, University of Louisville, Louisville, KY, USA.
Ting WangDepartment of Surgery, Division of Immunotherapy, University of Louisville, Louisville, KY, USA.
Jingzhi WangDepartment of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.
Yi TanPediatric Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY, USA.
Zhongbin DengDepartment of Surgery, Division of Immunotherapy, University of Louisville, Louisville, KY, USA.ORCID 0000-0003-1409-5824

Funding

Fibroblast Growth Factor 1 Prevents Hyperlipidemia and atherosclerosisR01HL160927 · NHLBI · UNIVERSITY OF LOUISVILLE · PI Yi Tan · 2022 to 2026
$2.7M
CSN8 regulation of S1P-enriched extracellular vesicles to modulate NAFLD by gut-liver axisR01DK115406 · NIDDK · UNIVERSITY OF LOUISVILLE · PI DENG, ZHONG-BIN · 2018 to 2022
$2.0M
Characterization of the role of neuropeptide VIP-mediated fucosylation in alcohol associated liver diseaseR01AA030756 · NIAAA · UNIVERSITY OF LOUISVILLE · PI Zhong-Bin Deng · 2023 to 2026
$1.8M
The role of neutral ceramidase in intestinal fucosylation and liver steatosis and inflammationR01DK131442 · NIDDK · UNIVERSITY OF LOUISVILLE · PI Zhong-Bin Deng · 2022 to 2026
$1.6M
NHLBI NIH HHS R01 HL160927NIAAA NIH HHS R01 AA030756NIDDK NIH HHS R01 DK115406NIDDK NIH HHS R01 DK131442
6 · The paper itself

Abstract

Commensal bacteria produce a diverse array of glycosylated molecules, including glycoproteins, glycolipids, peptidoglycan, capsular polysaccharides, and exopolysaccharides, which play fundamental roles in host-microbe interactions. Recent advances have highlighted the intricate mechanisms by which bacterial glycosylation contributes to immune regulation, epithelial barrier integrity, and microbial community stability, with implications for a range of conditions, including infectious diseases, chronic inflammatory disorders such as inflammatory bowel disease (IBD) and Alzheimer's disease, and metabolic diseases such as diet-induced obesity. This review provides a comprehensive synthesis of historical and recent insights into commensal bacterial glycosylation, emphasizing its role as a key mediator of host-bacteria interactions and its broader impact on gut homeostasis and systemic health.

Indexed as

BacteriaGastrointestinal MicrobiomeHost Microbial InteractionsAnimalsGlycosylationHumansSymbiosiscapsular polysaccharidescolitisglycolipidsGlycoproteinmetabolic disease

Identifiers

PMID40810484
PMCPMC12355684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.